Diphtheria toxoid, purified, adsorbed, with reduced antigen content, liquid – AD-M-anatoxin

"ADS" - vaccination against diphtheria and tetanus

Vaccine "ADS" combined, bivalent, - adsorbed diphtheria-tetanus toxoid Temporarily out of stock Manufacturer: Pharmstandard-Biolek CJSC, Ukraine Protects against diphtheria and tetanus: administration of the drug causes the formation of specific antitoxic immunity against these diseases. Suitable for use: for children aged 3 months, teenagers and adults. Included in the national calendar of preventive vaccinations in Russia.

Imovax D.T. Adultery

This is an imported analogue of French-made ADS-m. Available in the form of a suspension.

Composition and active substance

0.5 ml of suspension, making up one dose, contains:

• one dose of tetanus toxoid in an amount of at least 20 IU;
• one dose of diphtheria toxoid in an amount of at least 20 IU;
• sorbent – ​​aluminum hydroxide;
• preservative – thiomersal.

Purified diphtheria and tetanus toxoids are the active components of the vaccine.

The suspension can be released into:

• ampoules or syringes containing one dose;
• bottles of 10 or 20 doses.

Directions for use and dose

The drug is recommended to be administered intramuscularly. This will minimize the occurrence of local reactions. However, it is allowed to use the product subcutaneously. In both cases, the suspension must be shaken to make it homogeneous.

The dosage depends on the purpose of immunization.

1. Primary immunization - 3 doses (0.5 ml each) are administered at intervals of a month.
2. Revaccination - every ten years, one dose is administered - 0.5 ml.
3. Prevention of tetanus - administered together with antitetanus immunoglobulin. The dose depends on the nature of the wound and whether the patient has previously been vaccinated or not, and how much time has passed since the last revaccination.

Immunological properties

The main property of the drug is stimulation of the immune system. Its administration should lead to the development of specific immunity against diphtheria and tetanus, which intensifies a few days after vaccination and persists for five years.

Contraindications

Imovax D.T. Adultery should not be used in the following cases:

• allergy to vaccine components;
• chronic disease in the acute stage;
• acute infection;
• increased sensitivity to drug administration;
• neurological disorders.

Pregnancy and lactation are not contraindications for immunization with this drug, but it is still better to postpone its use.

If in doubt, you should consult your doctor.

Side effects

Like any other drug, Imovax is characterized by adverse reactions, although most often vaccination takes place without problems.

Local reactions are manifested by pain at the injection site, as well as the appearance of a compaction or subcutaneous nodule. Symptoms such as redness and itching cannot be excluded. All of them last no more than two days.

General reactions are hyperthermia, weakness, deterioration of health, rash, muscle and joint pain. They also go away in three days.

If after three days the side effects do not disappear, or your health worsens, you should seek help from a doctor.

Advantages of the ADS vaccine:

• vaccination with the ADS vaccine guarantees a high degree of protection against two dangerous infections simultaneously
• The administration of the ADS vaccine causes the formation of a persistent immune memory in the body. During revaccination, antitoxins are rapidly formed in high concentrations.
• administration of the ADS vaccine causes fewer allergic reactions compared to the DTP vaccine.
• it is possible to use the ADS vaccine for emergency vaccination within 20 days in case of injury and contact with the ground, in contact with patients, in epidemic foci
• the ADS vaccine can be administered simultaneously (on the same day) with any inactivated vaccines and live chickenpox vaccine, provided that the injections are carried out in different parts of the body

Vaccine AD-M toxoid

Purified diphtheria toxoid, adsorbed with reduced antigen content, liquid (AD-M toxoid).

International nonproprietary name: Diphtheria toxoid

Dosage form: Suspension for injection

Description

The suspension is grayish-white; upon settling, it is divided into two fractions - a transparent liquid and a loose sediment.

pharmachologic effect

Forms specific immunity against diphtheria.

Indications for use

Prevention of diphtheria in children from 6 years of age, adolescents and adults.

Contraindications

Hypersensitivity.

Dosage regimen

IM into the upper outer quadrant of the buttock or the anterior outer part of the thigh or deep subcutaneously (adolescents and adults) into the subscapular area in a single dose of 0.5 ml. Before vaccination, the ampoule must be thoroughly shaken until a homogeneous suspension is obtained. For planned age-related revaccinations, the drug is administered once to persons who have received a tetanus toxoid vaccination in connection with emergency prophylaxis of tetanus.

Side effect

Rarely (in the first 2 days) - hyperthermia, malaise, local reactions (pain, hyperemia, swelling); in isolated cases - allergic reactions (angioedema, urticaria, polymorphic rash), minor exacerbation of allergic diseases.

special instructions

Persons who have suffered acute diseases are vaccinated 2-4 weeks after recovery. In mild forms of the disease, vaccinations are allowed after the clinical symptoms disappear. Patients with chronic diseases are vaccinated after achieving complete or partial remission. Persons with neurological changes are vaccinated after progression of the process has been ruled out. For patients with allergic diseases, vaccinations are carried out 2-4 weeks after the end of the exacerbation, while stable manifestations of the disease (localized skin phenomena, hidden bronchospasm, etc.) are not contraindications to vaccination, which can be carried out against the background of appropriate therapy. Immunodeficiencies, HIV infection, as well as maintenance course therapy (including corticosteroids and neurotropic drugs) are not contraindications to vaccination. Pregnant women are vaccinated according to epidemiological indications. In order to identify contraindications, on the day of vaccination, the doctor conducts a survey of parents and examines those vaccinated with mandatory thermometry. When vaccinating adults, preliminary selection of persons to be vaccinated is allowed, with their interview by the medical worker conducting the vaccination on the day of vaccination. Persons temporarily exempt from vaccination must be monitored and registered and vaccinated in a timely manner. If epidemiologically necessary, the drug can be administered against the background of an acute illness. In case of a strong reaction to the previous dose of this drug, a second dose is administered while using GCS (prednisolone orally 1-1.5 mg/kg/day the day before and immediately after vaccination). The drug can be administered a month later or simultaneously with the polio vaccine and other drugs in the national vaccination calendar. Considering the possibility of developing immediate allergic reactions in particularly sensitive individuals, vaccinated individuals must be provided with medical supervision for 30 minutes. Vaccination sites must be provided with anti-shock therapy. For persons who have suffered severe forms of allergic reactions to the administration of the drug, further scheduled vaccinations of the drug are stopped. The drug is not suitable for use in ampoules with damaged integrity, lack of labeling, changes in physical properties (change in color, presence of unbreakable flakes), or improper storage. The opening of ampoules and the vaccination procedure are carried out in strict compliance with the rules of asepsis and antiseptics. The drug cannot be stored in an opened ampoule. The administration of the drug is registered in the established accounting forms, indicating the batch number, expiration date, manufacturer, and date of administration.

Contraindications

Only a doctor can decide whether ADS toxoid is suitable for vaccination

"ADS" is contraindicated if there is a history of an allergic reaction to any component of the vaccine, including aluminum and formaldehyde.

Contraindications for ADS vaccination:

1. severe reaction or post-vaccination complication to a previous vaccine administration;
2. acute infectious and non-infectious diseases - vaccinations are carried out no earlier than 2-4 weeks after recovery. For mild forms of disease (rhinitis, mild hyperemia of the pharynx, etc.), vaccination is allowed after the clinical symptoms disappear;
3. chronic diseases - vaccinations are carried out after achieving complete or partial remission;
4. neurological changes - vaccinated after the progression of the process has been ruled out;
5. history of seizures;
6. allergic diseases - vaccinations are carried out 2 - 4 weeks after the end of the exacerbation, while stable manifestations of the disease (localized skin phenomena, hidden bronchospasm, etc.) are not contraindications to vaccination, which can be carried out against the background of appropriate therapy;
7. immunodeficiencies, immunosuppressive therapy, HIV infection, cancer;
8. patients with allergic diseases are vaccinated 2 - 4 weeks after an exacerbation, while stable manifestations of the disease (localized skin manifestations, hidden bronchospasm, etc.) are not a contraindication to vaccination, which can be carried out against the background of appropriate therapy;
9. vaccinations for epidemiological indications: non-immune persons with the diseases specified in the section “Contraindications for use”, who are in direct contact with patients with diphtheria (family, class, dorm room, etc.), can be vaccinated according to the conclusion of a specialist until recovery (remission) ) against the background of appropriate therapy.

D.T. Wax

Another imported vaccine from France, designed to protect against dangerous infections.

Release form and composition

The drug is a suspension. One dose contains:

• purified diphtheria toxoid – at least 30 IU;
• purified tetanus toxoid – at least 40 IU;
• aluminum hydroxide;
• thiomersal as a preservative.

You can purchase the drug at:

• ampoules containing one dose (pack of 20 ampoules);
• single dose syringe;
• bottles of 10 or 20 doses, packed in boxes of 10 pieces.

pharmachologic effect

The action of the drug is aimed at building immunity against diphtheria and tetanus, which develops after the second injection and lasts for five years.

Restrictions on use

Stop using D.T. Vax is worth it if the patient:

• fever;
• exacerbation of a chronic illness;
• acute infection;
• allergy to the components of the product;
• Strong reactions were observed upon initial administration.

If the reactions were severe, it will be recommended to exclude diphtheria toxoid or reduce its dose.

Side effects

Negative consequences are observed very rarely. However, they may manifest themselves as the following symptoms:

• slight hyperthermia (passes in two days);
• compaction at the injection site (dissolves within a day or two).

More pronounced reactions are usually provoked by the diphtheria component, so if an allergy occurs, its dose should be reduced.

Possible side effects

"ADS" toxoid is one of the least reactogenic drugs. Some vaccinated people may develop short-term general (fever, malaise) and local (pain, hyperemia, infiltration, swelling) reactions in the first two days. Considering the possibility of developing immediate allergic reactions (Quincke's edema, urticaria, polymorphic rash, anaphylactic shock) in particularly sensitive individuals, vaccinated persons must be provided with medical supervision for 30 minutes. Vaccination sites must be provided with anti-shock therapy.

Come get vaccinated at ONNI.
A full range of vaccines for children and adults, family vaccinations - at a special price! Call a doctor at home Make an appointment with a doctor or call +7 (812) 331-17-74

Tetanus vaccination for children

Parents need to know that only preventive vaccination can provide reliable protection of the child from infectious diseases and from the serious complications and consequences they cause. At the same time, weakened children must be vaccinated first, since their bodies are especially susceptible to infection, which usually occurs in a severe form. The timing of vaccinations for such children is determined by the doctor.

Most parents are concerned about negative reactions to vaccinations. For example, numerous scientific studies and clinical observations have shown that even in children prone to allergies, vaccination usually does not cause allergic reactions. Variants of the norm are redness, swelling, pain at the injection site, as well as fever and tearfulness. As a rule, the appearance of such reactions is short-lived; your doctor will inform you about them in advance. If there is a risk of their development, we offer inpatient observation in our clinic.

Tetanus vaccination for adults

Immunization is no less important than for babies. If for some reason vaccination was not carried out in childhood, then 2 doses of tetanus toxoid are administered, with a break of a month between their administration. The third and final injection is given after 12 months, after which the countdown begins, and the vaccination is repeated every 10 years. This is a mandatory measure, since tetanus can be contracted at any age, especially for those who live in an epidemiologically unfavorable region. A separate category of citizens includes:

• students;
• military personnel;
• railroad workers and construction workers;
• diggers.

It is a common case that people simply do not remember the last date of vaccination. In this case, ADS-M is given twice with an interval of 45 days and revaccinated 6-9 months after the second dose. We guarantee you the safety of the procedure and are confident in the quality of the drugs used. Injections are performed by qualified medical personnel in compliance with all aseptic and antiseptic rules.

Tetanus vaccination schedule

Immunization within the framework of the national calendar of preventive vaccinations is carried out with medical products registered in accordance with the legislation of the Russian Federation.

Vaccines used

The effectiveness of tetanus toxoids has been documented. In most clinical trials, effectiveness ranges from 80% to 100%. For immunization, it is possible to use single and complex preparations. There are 4 types of tetanus vaccine:

1. DPT - contains killed whole pertussis bacillus, diphtheria and tetanus neutralized toxin.
2. ADS - does not contain the pertussis component, used for vaccinations against tetanus and diphtheria.
3. ADS-M is a Russian vaccine that has no complete analogues imported in Russia. Approved for use from 6 years of age.
4. AS is a tetanus toxin neutralized by formaldehyde and heat, purified from ballast proteins. Used for routine vaccination of persons who have not previously been vaccinated and for emergency prophylaxis.
5. Adasel is a new vaccine that is intended for revaccination and maintenance of immune memory. Can be used to complete the series of childhood vaccines from 4 years of age, as well as to protect the newborn from whooping cough when revaccinated during pregnancy from the 27th to the 36th week.

We invite you to get a tetanus vaccination at an affordable price at the Miracle Doctor clinic in Moscow. The procedure is carried out strictly according to indications and with permission from a doctor with the current date. If you do not have a referral for vaccination, you can undergo an examination with us. The dose schedule depends on previous vaccinations received, the urgency of the situation and the patient’s health status.

Scheme and method of administration of the ADS vaccine

The site of administration of the vaccine for newborns and young children is predominantly the anterolateral surface of the thigh (its middle third), and in children over three years of age it is recommended to administer the vaccine into the densest part of the deltoid muscle (muscle protrusion on the shoulder, in the upper third, the injection is given on the side ) in a dose of 0.5 ml (single dose).

The ADS vaccine can be used from 3 months to 6 years 11 months 29 days with an interval between the first and second doses of at least 1 month, and with an interval of at least 9 months between the second and third doses. Reducing intervals is not allowed. If it is necessary to increase vaccination intervals, the next vaccination should be carried out as soon as possible, which is determined by the child’s condition.

Children over 7 years of age and adults who have not previously been vaccinated or do not have vaccination data are given ADS vaccinations according to the instructions for use of the drug.

How to help your young child feel comfortable during vaccinations

Vaccination works better when the baby is calm and not afraid. To avoid scaring your child, try the following:

Distract and calm your baby, hug him, talk softly to him

Vaccine effectiveness

The effectiveness and efficiency of tetanus toxoids have been documented. In most clinical trials, effectiveness ranged from 80% to 100%. The introduction of tetanus vaccination in the United States in the 1940s caused the overall incidence of tetanus to decline from 0.4 per 100,000 population in 1947 to 0.02 per 100,000 population in the late 1990s. In a double-blind, controlled study conducted in rural Colombia, neonatal tetanus did not occur in neonates born to mothers receiving double or triple doses of the vaccine, while in an unvaccinated control group of neonates the mortality rate was 78 deaths per 1000 live births. The only means of prevention is vaccination, the effectiveness of which is 95-100%. Strong immunity against diphtheria and tetanus lasts approximately 5 years, after which it gradually fades, so revaccination against these diseases is required every 10 years.

Principles and purposes of vaccination

Since natural immunity does not exist, that is, immunity after an illness is short-lived, susceptibility to the disease is very high, and the course of the disease is extremely severe, with a high probability of death, you should be vaccinated against this dangerous infection. Tetanus can be rapidly prevented through immunization and vaccines containing tetanus toxoid, which are included in childhood immunization programs worldwide.

Isolated tetanus vaccination can be successfully used to immunize people of any age group, both children and adults. It is especially important to vaccinate pregnant women who have not previously been vaccinated against tetanus, as this can reduce the risk of maternal and neonatal (infant) tetanus to virtually zero. In addition, antibodies against tetanus are passed from mother to newborn, protecting the baby for two months. To develop full immunity to infection, it is necessary to administer five doses of tetanus vaccine. It is recommended that adults, especially women of childbearing age, be revaccinated throughout their lives, which will ensure immunity to infection for life. In Russia, adults are recommended to receive a booster vaccination against tetanus every 10 years.

Vaccination is carried out three times, with an interval of 45 days and a single revaccination 12 months after the 3rd vaccination, i.e. at 18 months of age. Further, according to the vaccination calendar, revaccination is carried out with ADS-M toxoid at 7 and 14 years of age and subsequently every 10 years. Emergency prevention of tetanus consists of primary surgical treatment of the wound and the simultaneous administration of a vaccine (ADS or ADS-M) and human tetanus immunoglobulin (TSHI), or purified concentrated antitetanus serum (PTS).

Risk of post-vaccination complications

As with any other vaccine, in rare cases allergic reactions to vaccine components are possible. These complications are not related to the properties of the vaccine, but to the amount of excipients in specific preparations, whether the child is allergic to them and, in some cases, non-compliance with vaccination rules. It is significant that, according to statistics of post-vaccination complications in the United States, even severe allergic reactions to DTP vaccines have not led to serious consequences in any case since 1978, taking into account the fact that about 80 million vaccinations were given during this period. Possible specific complications of DTP vaccines include neurological complications, which are extremely rare. It is assumed that they may be caused by the fact that the toxins of pertussis bacillus (even inactivated) in combination vaccines tend to irritate the meninges of an extremely small proportion of susceptible children. Complications in the form of encephalopathy are less than 1 case per 300 thousand vaccinated people.

Currently, in the world, convulsions without fever are not considered a complication of vaccination. Research conducted in Great Britain in 1960-1970. indicate the same frequency of seizures in vaccinated and unvaccinated children. Moreover, the first manifestations of diseases such as epilepsy, organic damage, and are associated with vaccination only by a temporary factor.

The development of afebrile seizures indicates the presence of an organic lesion of the nervous system in the child, which was not taken into account and identified or could not be identified before vaccination for objective reasons. Therefore, in the event of afebrile seizures, a comprehensive neurological examination is necessary to make a diagnosis.