Lincomycin for children for the treatment of infections of the ENT organs, stomatitis

pharmachologic effect

An antimicrobial agent that belongs to the group of lincosamides. Its bacteriostatic effect is noted in relation to a wide range of microorganisms. If higher doses of the drug are used, it may produce a bactericidal effect.

The mechanism of the antimicrobial effect of the antibiotic is as follows: under its influence, protein synthesis is inhibited in the cells of microorganisms. It has pronounced activity against gram-positive anaerobic and aerobic microorganisms. Resistance to the influence of the drug is demonstrated by strains of Enterococcus faecalis, as well as viruses, fungi, and protozoa. Most gram-negative microorganisms are also resistant to it. Slow development of resistance to this drug has been noted. Cross-resistance of this substance with clindamycin has been noted.

What is Lincomycin

So, here is a popular medicine, which in Latin recipes is called Lyncomycini hydrochloridi. Like any antimicrobial drug, it has its own characteristics of use and interactions with other drugs.

There are people with intolerance and various diseases for which this drug is contraindicated.

The antimicrobial drug Lincomycin is a broad-spectrum antibiotic, providing an active bacteriostatic/bactericidal effect against staphylococci, streptococci, mycoplasma, and other pathogenic microorganisms. How it works? The mechanism is simple. The substance interferes with the process of protein production inside bacterial cells.

Pharmacokinetics and pharmacodynamics

After oral administration, lincomycin hydrochloride is rapidly absorbed from the gastrointestinal tract. About 50% of the substance enters the systemic circulation. It is 75% bound to plasma proteins, the highest concentration is observed 2-4 hours after oral administration. The substance penetrates into fluids and organ tissues. The highest concentrations are observed in saliva, kidneys, genitals, liver, heart muscle, bone tissue, and bronchial secretions. Able to penetrate the blood-brain barrier, it is excreted in breast milk. Metabolism mainly occurs in the liver, it is excreted from the body in feces, a small amount is also excreted in the urine as metabolites and unchanged. The half-life from the body is 5-6 hours, it increases in people suffering from kidney disease.

Popular analogues and substitutes

Lincomycin is widely used in dentistry for the formation of painful inflammatory processes. The drug is available in various forms, such as ointments, tablets, and injection ampoules. If there are contraindications, selection of analogues may be required.

Despite the similar effect, the dosage of the drugs is different. The doctor relies on the patient’s condition, the rate of development of the infection, and the complexity of the disease. When independently selecting a substitute or a generic, pay attention to the cost, active ingredient, the presence of contraindications, and the risk of negative reactions.

Features of the drug Lincocin

A popular drug to replace Lincomycin. Almost identical in composition and method of action on pathogenic microflora. Lincocin capsules are rarely prescribed; the ampoule form is more often used. In liquid form, a highly concentrated drug helps with:

• osteomyelitis;
• purulent arthritis;
• purulent complications;
• wound infection;
• infectious lesions of the mucous membrane;
• pleurisy;
• sepsis;
• furunculosis.

It has a large number of side effects and should be used with caution. Prohibited for any impairment of kidney or liver function. Overdose rarely causes anaphylaxis, erythema multiforme, aplastic anemia, and agranulocytosis. Often, when the dosage is increased, the following reactions occur:

• nausea;
• vomit;
• abdominal discomfort;
• single failure of the gastrointestinal tract;
• diarrhea;
• glossitis;
• stomatitis.

Lincocin can act as a full-fledged substitute for Lincomycin due to the lack of the original drug. Located in the same price category. The speed of exposure is identical, removal from the body is similar.

Neloren as a complete substitute

Fights staphylococcal, streptococcal infections, resistant pathogenic microorganisms. Affects more bacteria than Lincomycin. Applicable for:

• purulent lesions;
• bacterial infections;
• purulent complications;
• infections of tissue, mucous membranes.

In dentistry it is used as an analogue of Lincomycin. Prohibited during pregnancy, kidney or liver dysfunction. It also accumulates in bone tissue, protecting it from the penetration of infected microorganisms. It takes longer to be eliminated from the body, as it has a prolonged effect. Compatible with most broad-spectrum antibiotics.

Increases bilirubin and the level of liver transaminases when the dosage is exceeded. Possible phlebitis, decreased blood pressure. More often, adverse reactions are limited to dizziness and mild nausea. In comparison with Lincomycin, it loses in the percentage of negative reactions. Replaced with similar products without loss of effectiveness.

Ceftriaxone against infection, bacteria

A common analogue of Lincomycin. It has a wide spectrum of bactericidal effects, helps against gram-positive and gram-negative bacteria. The mechanism of action is different. Ceftriaxone disrupts the integrity of the bacterial cell membrane. Maintains prolonged effectiveness. Approved for use by pregnant women and newborns.

Ceftriaxone is only suitable for intramuscular, intravenous administration.

Prescribed for bacterial pathologies, lesions in the abdominal cavity, lungs. Used in dentistry to prevent the development of pathogenic microflora.

Does not accumulate in bone tissue. It is completely excreted from the body unchanged and does not disintegrate. One of these drugs that can be used for meningitis.

Contraindications include sensitivity to the components of the drug, renal and liver failure. Allergic reactions in the form of rash and swelling may occur. There are functional intestinal disorders and decreased immunity. Candidiasis may develop against the background of suppressed immune system.

Popular substitute Doxycycline

A drug belonging to the category of tetracycles. Stops protein synthesis inside pathogenic bacteria, stops the growth of infected microflora. Active against Shigella, Salmonella, pneumococci, staphylococci, streptococci. It specifically affects bone tissue due to the formation of compounds with calcium salts. You need to take capsules according to the schedule. The following adverse reactions are observed:

• hypersensitivity reaction;
• rash, itching, swelling;
• suppression of bleeding;
• violation of the formation of tooth enamel;
• pain in joints, muscles;
• increased enzymes in the liver.

An overdose is characterized by blurred vision, intense headaches, dizziness, and increased intracranial pressure. Disorder of the digestive system manifests itself to varying degrees. Prohibited during pregnancy and breastfeeding. Not prescribed to children under five years of age; up to fourteen years of age the dosage is significantly reduced. It is used as an independent drug, less often in combination with other antibiotics.

Doxycycline is prohibited for porphyria and various liver diseases, even without loss of functionality. Used in dentistry as a targeted combined action antibiotic. Prevents the development of a number of diseases. Prevents infection in the presence of damage in the oral cavity.

Indications for use of Lincomycin

Lincomycin tablets and Lincomycin injections are prescribed for the following diseases:

• diseases of the bones and joints of an infectious nature, the development of which was provoked by microorganisms sensitive to the drug ( osteomyelitis , septic arthritis );
• infectious diseases of the ENT organs and respiratory tract, provoked by sensitive microorganisms (used for sore throat , sinusitis , otitis , bronchitis , pneumonia , tracheitis , etc.);
• diseases of the skin and soft tissues, which are provoked by microorganisms sensitive to the product ( abscess , purulent wounds , mastitis , furunculosis , erysipelas , etc.).
• Lincomycin-AKOS is used externally for inflammatory and purulent diseases of soft tissues and skin, which were caused by microorganisms sensitive to the active ingredient.

Lincomycin is used in dentistry to treat purulent and infectious processes that occur in the oral cavity. In particular, Lincomycin in dentistry can be prescribed for the treatment of periodontitis , periodontitis , gingivitis , purulent abscesses , etc. Whether there are indications for the use of Lincomycin is determined by the dentist individually.

Advantages of Lincomycin over analogues

Regardless of the form of release, the drug is active for several hours. Positive effects of using Lincomycin:

1. Detrimental effect on bacteria. Increasing the body's resistance to bacterial infections.
2. Cumulative effect. The active substance is concentrated in the bone tissue and does not damage the jaw bones.
3. Relieving inflammation. Actively fights inflammatory processes in tissues and mucous membranes. Relieves pain.
4. High activity. Retains functionality for a long period of time and does not allow bacteria to develop resistance.

Lincomycin-AKOS is an ointment for external use. Light homogeneous mass with the active ingredient lincomycin hydrochloride. Helps in the short term with diseases of soft tissues and skin. It has a minimum number of equivalent analogues and has virtually no contraindications or adverse reactions. There is no smell or taste.

Tablets for internal use contain the active substance in high concentration. Helps cope with infectious diseases, bacterial lesions of the skin and mucous membranes. Has a bacteriostatic effect.

Side effects

When using Lincomycin in ampoules and capsules, patients may experience the following side effects:

• dysfunctions of the gastrointestinal tract ( vomiting , pain, nausea , stool disorders, increased activity of liver enzymes, esophagitis , hyperbilirubinemia );
• disorders of the hematopoietic process ( thrombocytopenia , agranulocytosis , neutropenia , pancytopenia );
• allergic processes ( skin itching , urticaria , rash , swelling erythema multiforme , anaphylactic shock );
• muscle weakness, headaches , arterial hypertension , dizziness .

If you experience any side effects, you should immediately tell your doctor about it.

Instructions for use of Lincomycin (Method and dosage)

If the patient has been prescribed Lincomycin injections, the instructions for use must be carefully followed during the treatment process. The drug in ampoules can be administered intravenously and intramuscularly. The daily dose of the drug for an adult patient should be no more than 1.8 g; if the disease is severe, the doctor can increase it to 2.4 g. The drug is administered three times a day, with the interval between injections being 8 hours. For children, the drug should be administered at a dose of 10-20 mg per 1 kg of body weight per day. Lincomycin is administered intravenously by drip; before administration, the solution is diluted with an isotonic sodium chloride solution.

For infectious diseases, Lincomycin capsules are also prescribed. The instructions for use recommend taking the drug in capsules for sore throat, as well as for sinusitis, either 1 hour before a meal, or 2 hours after taking it. The tablets cannot be chewed, they must be swallowed whole with plenty of liquid. The drug in tablets should be taken at regular intervals, dividing its daily dose. For children whose body weight exceeds 25 kg, the daily dose should be determined at the rate of 30 mg of the drug per 1 kg of weight.

When using the medicine in dentistry, as well as in the treatment of other infectious diseases, as a rule, Lincomycin is prescribed 500 mg three times a day. For severe symptoms, the dose can be increased to 500 mg of the drug four times a day. As a rule, the course of treatment lasts from 1 to 2 weeks. Sometimes the duration of treatment is up to 3 weeks (for example, with osteomyelitis ). If the patient has liver or kidney dysfunction, the dose should be adjusted individually.

Lincomycin ointment is prescribed externally. The instructions for use indicate that Lincomycin-AKOS ointment should be applied directly to the affected area in a thin layer. This procedure must be done 2-3 times a day.

Contraindications

Lincomycin should not be used for treatment in the following cases:

• Young children - up to 1 month for solution, up to 3 years for ointments and tablets;
• Intolerance to any component of the drug;
• If you have an allergic reaction to clindamycin;
• For severe liver and kidney diseases.

The medication should be given with caution in the presence of fungal infections of the skin and mucous membranes.

Interaction

If an antibiotic is used at the same time as non-steroidal anti-inflammatory drugs, the patient is more likely to develop respiratory failure and may experience respiratory arrest.

Taking Lincomycin and antidiarrheals simultaneously increases the likelihood of developing pseudomembranous colitis.

You cannot treat with the drug at the same time as using muscle relaxants and inhalational anesthetics.

Antibiotic absorption is reduced when taking adsorbent drugs simultaneously.

Lincomycin reduces the severity of the action of neostigmine , pyridostigmine , ambenonium .

The bacteriostatic effect of the antibiotic is reduced by simultaneous administration of Erythromycin and chloramphenicol .

Pharmaceutical incompatibility with kanamycin , novobiocin , and ampicillin .

special instructions

If the patient has impaired renal or liver function, the single dose of the drug is reduced by 1/3-1/2, and the interval between administration is increased. With prolonged antibiotic treatment, the condition of the liver and kidneys must be monitored.

If the patient has renal or liver failure, the drug is contraindicated, for which Lincomycin can be prescribed exclusively for health reasons.

If a patient is prescribed Lincomycin tablets, which subsequently develops pseudomembranous colitis as a side effect, the drug is discontinued and Bacitracin or Vancomycin .

Externally, the ointment is carefully prescribed for dermatomycosis .

The solution should not be administered rapidly intravenously

Lyncomycin capsule

Instructions for medical use of the drug

Description of pharmacological action

Suppresses bacterial protein synthesis due to reversible binding to the 50S ribosomal subunit and disrupts the formation of peptide bonds. Effective against gram-positive microorganisms (Staphylococcus spp., Streptococcus spp., including Streptococcus pneumoniae, Corynebacterium diphtheriae), some anaerobic spore-forming bacteria (Clostridium spp.) and gram-negative anaerobes (Bacteroides spp., Mycoplasma spp.). Acts on microorganisms (especially Staphylococcus spp.) resistant to other antibiotics. Enterococcus spp. are not sensitive to lincomycin. (including Enterococcus faecalis), gram-negative microorganisms, fungi, viruses, protozoa. Inferior to erythromycin in activity against spore-forming anaerobes, Neisseria spp., Corynebacterium spp. Resistance develops slowly. Cross-resistance exists between lincomycin and clindamycin. In therapeutic doses it has a bacteriostatic effect, in higher doses and against highly sensitive microorganisms it has a bactericidal effect.

Indications for use

Staphylococcal infections, sepsis, osteomyelitis.

Release form

capsules 250 mg; dark glass jar (jar) 20 cardboard box (box) 1; capsules 250 mg; dark glass jar (jar) 20 cardboard pack 1; capsules 250 mg; dark glass jar (jar) 20 cardboard box (box) 18; capsules 250 mg; dark glass jar (jar) 10 cardboard pack 1; capsules 250 mg; polymer jar (jar) 10 cardboard pack 1; capsules 250 mg; polymer jar (jar) 20 cardboard pack 1; capsules 250 mg; polymer bottle (bottle) 20 cardboard pack 1; capsules 250 mg; contour packaging 10 cardboard pack 2; capsules 250 mg; contour packaging 10 cardboard box (box) 150; capsules 250 mg; contour packaging 10 cardboard pack 1;

Pharmacokinetics

When taken orally on an empty stomach, approximately 20–30% of the dose is absorbed (food intake significantly reduces absorption, bioavailability when taken after meals is 5%), Cmax in the blood is reached after 2–4 hours. It is well and quickly distributed into most tissues and body fluids (except for cerebrospinal fluid), high concentrations are created in bile and bone tissue. Does not pass through the BBB well. It quickly passes through the placenta, concentrations in the fetal blood serum are 25% of the concentration in the maternal blood. Passes into breast milk. Metabolized in the liver. T1/2 with normal renal function is 4-6 hours, with end-stage kidney disease - 10-20 hours, with impaired liver function T1/2 increases by 2 times. It is excreted unchanged and in the form of metabolites with bile and kidneys. When taken orally, 30–40% of the dose is excreted unchanged in feces within 72 hours. Hemodialysis and peritoneal dialysis are not effective in removing lincomycin from the body.

Use during pregnancy

Contraindicated during pregnancy (except when necessary for health reasons). FDA category of effect on the fetus is C. Breastfeeding should be discontinued during treatment.

Contraindications for use

Hypersensitivity, severe hepatic and/or renal failure, early infancy (up to 1 month).

Side effects

From the gastrointestinal tract: nausea, vomiting, diarrhea, abdominal pain, glossitis, stomatitis, transient hyperbilirubinemia, increased activity of liver transaminases; with long-term use - gastrointestinal candidiasis, antibiotic-associated diarrhea, pseudomembranous enterocolitis. From the hematopoietic organs: reversible leukopenia, thrombocytopenia, neutropenia. Allergic reactions: urticaria, exfoliative dermatitis, angioedema, anaphylactic shock. Other: local reactions with intravenous administration - phlebitis; with rapid intravenous administration - decreased blood pressure, dizziness, asthenia, relaxation of skeletal muscles.

Directions for use and doses

Inside, 1-2 hours before meals. Adults and children over 12 years old - 500 mg 3-4 times a day. The duration of treatment, depending on the form and severity of the disease, is 7-14 days (for osteomyelitis - 3 weeks or more). For long-term or repeated courses, treatment should be carried out under monitoring of liver and kidney function.

Overdose

Symptoms: increased side effects from the digestive system. Treatment: gastric lavage, taking activated carbon, symptomatic therapy.

Interactions with other drugs

Antagonism is possible when used simultaneously with erythromycin, chloramphenicol, ampicillin and other bactericidal antibiotics, synergism with aminoglycosides. Antidiarrheal drugs reduce the effect of lincomycin (the interval between their use should be at least 4 hours). Strengthens the effect of drugs for inhalation anesthesia, muscle relaxants and opioid analgesics, increasing the risk of neuromuscular blockade and respiratory arrest. Pharmaceutically incompatible with kanamycin and novobiocin.

Precautions for use

Should not be combined with muscle relaxants. For severe infections, lincomycin is combined with aminoglycosides or other antibiotics that act on gram-negative bacteria. Prescription to patients with liver failure is permissible only for health reasons. With long-term use, systematic monitoring of renal and liver function is necessary. If pseudomembranous colitis develops, discontinue treatment and administer vancomycin or bacitracin. Rapid intravenous administration should be avoided. When applied topically, caution should be exercised in case of dermatomycosis.

Storage conditions

List B.: In a dry place, protected from light, at a temperature not exceeding 20 °C.

Best before date

36 months

ATX classification:

J Antimicrobials for systemic use

J01 Antimicrobials for systemic use

J01F Macrolides and lincosamides

J01FF Lincosamides

J01FF02 Lincomycin

Analogs

Level 4 ATC code matches:
Clindamycin

Lincomycin Hydrochloride

Analogues of the antibiotic Lincomycin are the drugs Lincomycin hydrochloride , Linkocin Clindamycin , Dalatsin C , Clindamycin-Norton , etc.

The use of other drugs by patients prescribed Lincomycin without the prior approval of a physician is strictly prohibited.

Price and analogues

Cost of the drug:

• Lincomycin in capsules 0.25 g (20 pcs.) – from 90 rubles;
• Lincomycin ampoules 30%, 1 ml (10 pcs.) – from 150 rubles;
• Lincomycin ointment 2% (15 g) – from 88 rubles.

The drug is available in pharmacies with a prescription. The medication should be stored away from children in a dark, dry place at a temperature of 15-25°C. The solution and tablets are valid for 4 years, and ointments for 2 years.

On sale you can find medicines that are similar in active substance and therapeutic effect. There are domestic and imported analogues of the drug:

• Clindamycin;
• Clindacil;
• Clindamycin-Norton;
• Ecolink;
• Dalatsin;
• Lincocel;
• Lincocin;
• Clindahexal;
• Pulxipron.

You can change the prescribed drug to an analogue only with the consent of the attending physician. Reviews show that the drug is indispensable for purulent dental processes. The downside of the drug is its strong negative effect on the gastrointestinal tract.

With alcohol

When discussing the compatibility of this antibiotic with alcohol, it should be noted that alcohol should not be consumed while being treated with this medicine. This combination will disrupt the absorption of the active substance of the drug in the gastrointestinal tract; under the influence of alcohol on the liver, an acceleration of the half-life of the active substance is observed. Consequently, the concentration of the drug in the body decreases, and its effectiveness decreases.

In addition, if a patient combines Lincomycin and alcohol, the consequences can be negative, as the likelihood of side effects increases.

Reviews about Lincomycin

Reviews of Lincomycin that users leave online indicate that this drug has a pronounced antimicrobial effect and allows you to quickly get rid of the unpleasant symptoms of infectious diseases. Those who have used Lincomycin injections also leave mostly positive reviews.

Both when administered intravenously and intramuscularly, the solution acts quickly and reduces the severity of symptoms. Reviews about the use of the product in dentistry often contain information that the drug helped to quickly get rid of purulent and inflammatory diseases.

Lincomycin price, where to buy

The price of Lincomycin in ampoules averages from 40 rubles for 10 ampoules of 1 ml.

The price of Lincomycin tablets ranges from 60 to 90 rubles for 20 pieces. You can buy the drug in capsules in Ukraine for an average of 25 UAH. (30 pcs.).

Lincomycin-AKOS ointment can be purchased at a price of 27 rubles.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Lincomycin capsules 250 mg 20 pcs. Ozon LLC
  119 rub. order
• Lincomycin capsules 250 mg 20 pcs. BelmedpreparatyRUUE Belmedpreparaty

  67 RUR order

• Lincomycin hydrochloride solution for intravenous and intramuscular injection. 30% amp. 1ml 10 pcs. RUP Belmedpreparaty

  88 rub. order

• Lincomycin capsules 250 mg 20 pcs. Medicine production LLC

  86 rub. order

• Lincomycin hydrochloride solution for injection. 30% 1ml 10 pcs. JSC Dalkhimfarm

  113 RUR order

Pharmacy Dialogue

• Lincomycin hydrochloride (amp. 30% 1 ml No. 10) Belmedpreparaty

  80 rub. order

• Lincomycin hydrochloride (amp. 30% 1 ml No. 10) DHF JSC

  88 rub. order

• Lincomycin (caps. 250 mg No. 20) Belmedpreparaty

  72 RUR order

• Lincomycin h/x (caps. 250 mg No. 20)Production of medicines

  64 RUR order

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Pharmacy24

• Lincomycin-Darnitsa 30% 1 ml No. 10 solution
  37 UAH. order
• Lincomycin KMP 250 mg N30 capsules PAT "Kievmedpreparat", Ukraine

  35 UAH order

• Lincomycin-Darnitsa 30% 2 ml No. 10 solution for injection

  54 UAH order

• Lincomycin 300 mg/ml 1 ml No. 10 solution TOV" Pharmaceutical company "Zdorovya", Kharkiv, Ukraine

  34 UAH order

• Lincomycin 0.25 N20 capsules PAT NEC "Borshchagivsky chemical-pharmaceutical plant", Kiev, Ukraine

  32 UAH order

PaniPharmacy

• Lincomycin capsule Lincomycin capsules 0.25g No. 30 Ukraine, Kievmedpreparat OJSC

  42 UAH order

• LINCOMYCIN ampoule Lincomycin solution for injection 30% ampoule 1 ml No. 10 Ukraine, Health LLC

  35 UAH order

• Lincomycin ampoule Lincomycin solution for injection 30% ampoule 1 ml No. 10 Ukraine, Darnitsa ChAO

  41 UAH order

• LINCOMYCIN ampoule Lincomycin solution for injection 30% ampoule 2ml No. 10 Ukraine, Health LLC

  53 UAH order

• Lincomycin ampoule Lincomycin solution for injection 30% ampoule 2ml No. 10 Ukraine, Darnitsa ChAO

  56 UAH order

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Release form and composition

The drug is available in three forms: capsules (tablets), ointment and solution for injection. Main active ingredient: lincomycin hydrochloride.