Cycloferon: how to take and contraindications

Composition and dosage forms

The active substance of the drug is meglumine acridone acetate - acridone acetic acid. It is a stimulator of interferon production, which has an antimicrobial, anti-inflammatory effect and inhibits the development of tumors.

Cycloferon is produced in forms for oral, parenteral and local use:

Coated tablets: brown or yellow, biconvex. The composition includes: 150 mg of active substance, methylcellulose and calcium stearate as auxiliary compounds. Packages contain 10 and 50 pcs.
Injection. Transparent yellowish liquid in 2 ml ampoules. The content of meglumine acridone acetate is 250 mg per ampoule. Additional components: water and stabilizers.
Liniment for topical use: a thick, gel-like yellow substance containing 5% active substance. Available in 5 ml tubes.

Cycloferon price, where to buy

The average price of Cycloferon No. 10 tablets is 150 rubles.

The price of Cycloferon in ampoules is on average 300 rubles per pack of 5 ampoules. The price of Cycloferon injections in Ukraine (Kyiv, Kharkov and other cities) is from 150 to 160 hryvnia for 5 ampoules. You can buy ampoules at a lower price by ordering online. How much an injection solution or tablet costs should be found in a specific pharmacy chain.

The price of Cycloferon ointment is on average 270 rubles per 30 ml. Liniment can also be bought in Ukraine, its cost is from 100 to 120 hryvnia per 30 ml.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Cycloferon tablets p.p.o.
enteric solution 150 mg 20 pcs. LLC NTFF POLYSAN 386 rub. order
Cycloferon solution for intravenous and intramuscular administration. 125mg/ml 2ml 5 pcs. LLC NTFF POLYSAN
RUB 356 order

Pharmacy Dialogue

Cycloferon (tab. 150 mg No. 10) Polisan NTFF
RUB 204 order
Cycloferon (tab. 150 mg No. 20) Polisan NTFF
412 rub. order
Cycloferon (tab. 150 mg No. 50) Polisan NTFF
RUB 828 order
Cycloferon (amp. 12.5% 2ml No. 5) Polisan NTFF
RUB 323 order
Cycloferon (tab. 150 mg No. 50) Polisan NTFF
934 rub. order

Pharmacy24

Cycloferon 2 ml N5 solution TOV NTFF Polisan, Russian Federation
239 UAH order
Cycloferon 150 mg No. 10 tablets TOV NTFF Polisan, Russian Federation
111 UAH order
Cycloferon 150 mg N50 tablets TOV NTFF Polisan, Russian Federation
452 UAH order

PaniPharmacy

Cycloferon tablets Cycloferon tablets. 150 mg No. 10 Russia, Polisan
120 UAH order
Cycloferon ampoule Cycloferon injection solution 12.5% 2ml ampoules No. 5 Russia, Polisan
299 UAH order
Cycloferon tablets Cycloferon tablets. 150 mg No. 50 Russia, Polisan
484 UAH order

Mechanism of action of Cycloferon

The drug corrects the body's immunity by activating the production of interferons. When administered orally, meglumine is concentrated in the tissues of the liver, spleen, lungs, and intestines, on which the production of lymphocytes depends. Cycloferon also accelerates the release of granulocytes in the bone marrow.

The medicine inhibits autoimmune processes, reducing the body's pathological reaction to rheumatoid arthritis and other systemic diseases, and reduces the body's negative reactions during chemotherapy. When applied topically, the ointment reduces inflammation and has an antiproliferative effect.

The highest concentration of Cycloferon in the body is observed 2.5–3 hours after administration. Over the next 4–5 hours, it decreases by half. Complete elimination of the drug takes 1–1.5 days. The active substance is not deposited in tissues, does not provoke mutation processes, and does not cause intoxication.

Indications

Cycloferon is used in patients from 4 years of age:

in the treatment of herpetic infections;
for neuroinfections;
cytomegalovirus;
intestinal inflammation of a viral nature;
for the treatment of acute respiratory viral infections, acute respiratory infections;
in the complex treatment of viral hepatitis, HIV.

Liniment is used in the treatment of urogenital infections. The solution is also indicated for chlamydia and connective tissue diseases.

Acyclovir: injections for herpes

Injections for herpes are given intramuscularly.

This ensures rapid entry of the drug into the body and a higher therapeutic effect.

Virostatic agents containing a substance known as acyclovir are particularly effective.

These medications can be used as ointments, tablets, or intravenous injections.

Serious herpes infections must be treated with large doses of acyclovir, given regularly in parenteral form.

The most effective injections for herpes:

Acyclovir

Nucleoside analogue with selective action.

Acyclovir is an antiviral drug.

Slows down the growth and spread of the herpes virus, allowing the body to fight the infection.

Acyclovir cannot completely eliminate the herpes virus, but it can reduce the severity of the infection.

Acyclovir injection is used to treat severe illnesses caused by herpes viruses.

Including severe forms of genital herpes, encephalitis (brain swelling), Varicella–Zoster virus.

Injections against herpes with Acyclovir help prevent the formation of new rashes.

Minimizes the risk of complications due to the infectious process.

The drug accelerates the formation of crusts and reduces the severity of pain in patients with Herpes zoster (shingles/herpes).

Dosage and regimen of Acyclovir: one ampoule of the drug is diluted in 10 ml of 0.9% NaCl solution.

The medication is administered intravenously, slowly, over 60 minutes.

The product can also be administered dropwise, after diluting it in 100 ml of isotonic solution.

It is recommended to stop using Acyclovir if the following side effects develop:

decreased urination, change in urine color
the appearance of fever, chills, body aches, flu symptoms
deterioration of the skin (redness, peeling, itching)
development of jaundice (yellowing of the skin and mucous membranes of the eyes)
swelling, tenderness, change in skin color at the injection site
fatigue, deterioration of health, increased body temperature.

Less serious side effects may include:

nausea, vomiting, diarrhea, stomach pain, loss of appetite
muscle pain, numbness or tingling in the lower extremities
loss of coordination
drowsiness, loss of appetite
headache, feeling dizzy

The development of an acute allergic reaction during the use of the drug is extremely rare.

Mainly due to incorrect dosing.

If any adverse reaction develops, even minor, it is recommended to consult a doctor and consult about the need to change the medication.

The drug is not prescribed if there is an allergic reaction to the active components of the medication.

And also in case of intolerance to the drug Valaciclovir.

Acyclovir does not prevent the spread of genital herpes.

Avoid sexual intercourse or use a latex condom to prevent spreading the virus and infecting your sexual partner.

Cycloferon injections for herpes

The use of the basic regimen of Cycloferon injections for herpes has an antiviral and immunostimulating effect.

The drug is a kind of inducer involved in the formation of endogenous interferon.

Interferon is a type of cytokine family originally identified as a factor that suppresses viral infection.

Additionally, the medication reduces the severity of the inflammatory reaction and has a slight antitumor effect.

Especially manifested in relation to papillomas/condylomas with HPV.

During the use of the drug, autoimmune reactions are suppressed.

The severity of pain and inflammation in the epidermis is reduced.

The drug reduces the severity of the symptomatic picture of viral pathology.

It starts the process of activating the immune system and has a bacteriostatic effect.

The effectiveness of the drug allows it to be prescribed for chlamydia infection.

When diagnosed with herpes, injections with Cycloferon are prescribed according to the following scheme: 1st day, 2nd, then on the 4th and 6th and 8th days.

After a two-day break, the injection is administered on days 11, 14 and 17, then on days 23, 26 and 29.

The drug is administered intramuscularly or intravenously, depending on the doctor’s recommendations.

The injection is given once a day.

Cycloferon has virtually no contraindications.

Not prescribed for liver cirrhosis and intolerance to the components of the drug.

The drug is not prescribed during pregnancy and lactation.

Has excellent compatibility with other medications.

Polyoxidonium injections for herpes

Polyoxidonium is a powerful immune stimulant.

Its use leads to a significant activation of the immune system's ability to respond to foreign antigens.

It “turns off” pathogenic microorganisms, soluble toxins, and other harmful microparticles.

The pharmacological action of the drug is represented by its following abilities:

Polyoxidonium activates three subpopulations of phagocytes: the movement of resident macrophages, phagocytes of the blood supply and phagocytes of the reticuloendothelial tissue. This action is expressed in the activation of macrophage migration, their ability to capture and digest pathogenic microorganisms.
The medication increases the efficiency of interaction between T and B lymphocytes in antibody production reactions as a response to pathogens.
When stimulating the reactions of the immune system, Polyoxidonium does not disrupt the natural process of their inhibition.

Polyoxidonium is recommended for use as additional therapy for the following conditions:

Diseases of viral, infectious and bacteriological etiology, including those occurring in a chronic form.
Complications in the postoperative period, accompanied by purulent-septic lesions.
The drug is prescribed to patients after undergoing a course of cancer therapy.
Recommended as a prevention of toxic effects on the liver and kidneys when taking potent medications.
To accelerate the regenerative capabilities of the body in case of fractures, sprains, burns.
Prescribed to increase the effectiveness of treatment of pathologies of the musculoskeletal system and joint tissue.
For acute infectious and inflammatory pathologies of the urogenital tract in men and women.
As maintenance therapy in the presence of HIV infection or AIDS.

For children older than six months, the drug can be prescribed as the main method of treatment in the following cases:

Diseases of a viral or infectious nature, occurring in acute as well as chronic forms.
Pathologies of the allergic type, which are accompanied by the development of a number of complications: bronchial asthma, eczema, acute dermatitis.

Injections with the drug Polyoxidonium are prescribed to patients with ongoing herpes as a means of increasing the protective functions of the immune system.

However, it is worth remembering that this is just a drug that complements the main treatment.

Therefore, when treating a herpetic infection, an antiviral agent is prescribed.

Injections for herpes: Panavir

Panavir is a herbal preparation.

Contains an extract from the shoots of the plant Solanum tuberosum (potato, Solanaceae family).

Solanum tuberosum contains a hexose glycoside.

Glycosides are used by plants to protect against pathogenic microorganisms.

Hexose glycoside is used by the pharmaceutical industry for its pharmacological effects.

It reduces the inflammatory response by inhibiting histamine and provides an anticonvulsant and antiviral effect.

The action of Panavir is aimed at increasing nonspecific immunity and increasing the production of interferon by blood cells.

The drug is quite well tolerated.

Does not have a toxic effect on the liver and kidneys, does not affect the development of the embryo.

It was found that Panavir has minor anti-inflammatory and analgesic effects.

For herpes, injections with Panavir accelerate the body's regenerative capabilities.

This promotes the rapid formation of crusts and healing of herpetic eruptions.

Intravenous antiherpetic agents, such as Panavir, are intended for slow bolus administration.

The drug is not recommended to be mixed with other antiviral agents.

Adult patients with a herpetic infection are prescribed 5 ml of medication.

The drug is administered every 24 or 48 hours.

Depending on the patient’s condition and how acute the infectious process is.

If necessary, the course can be repeated after 4-6 weeks.

Allokin: injections for herpes

Allokin-Alpha is an antiviral drug with proven effectiveness against hepatitis B, C, herpes infection and HPV.

The main active ingredient of the drug is alloferon.

Alloferon is a peptide with 13 amino acids.

Isolated from bacteria-infected larvae of the moth fly Calliphora vicina.

The pharmaceutical value of the peptide has been well demonstrated by its ability to stimulate NK and interferon (IFN) cytotoxic activity in animal and human models.

In addition, the peptide proved to be an enhancer of antiviral and antitumor activity.

The antiviral and immunomodulatory effectiveness of alloferon has also been confirmed clinically.

In patients suffering from herpes simplex viruses (HSV) and human papillomavirus (HPV).

The drug is a low-toxic drug, well tolerated, and does not provoke the development of an allergic reaction.

Also, Allokin does not cause problems with the reproductive system.

Allokin injections showed good therapeutic results for the diagnosis of herpes zoster.

The medication is available in powder form for preparing a solution.

The product must be used immediately; it must not be stored in prepared form.

Allokin injections for herpes are usually used according to the following scheme: 1 ml of the drug is administered every 48 hours.

The total number of injections is no more than 3.

Injections with Allokin can be used against intimate zone herpes and HPV.

In case of an acute infectious process, the number of injections can be increased to 6.

The drug should be stored in the refrigerator, in powder form, for no more than two years from the date of production.

Cycloferon for genital herpes

In addition to systemic therapy, applications with Cycloferon liniment are used:

a thin layer of the product is applied to the affected areas daily for 5–7 days;
use the drug for intravaginal or transurethral instillation, injecting 5 ml daily for 2 weeks;
cotton swabs soaked in ointment are inserted into the vagina for 10–15 days.

Cycloferon ointment can be alternated with the use of other topical drugs.

CYCLOFERON in practical gynecology

In Ukraine, there is an increase in the number of gynecological diseases, in the pathogenesis of which disorders of the immune status are of paramount importance (Gutnev A.L., 2002). These are diseases of infectious origin (chlamydia, mycoplasmosis, candidiasis, genital herpes, cytomegalovirus infection, etc.), as well as pathology caused by dyshormonal heterotopic tissue proliferation (genital endometriosis).

The most important factor in the body's nonspecific defense against foreign tissue is the interferon-cytokine system, which is characterized by antiviral activity, immunocorrective and anticarcinogenic effects. To restore the function of this part of the immune system in gynecology, inducers of endogenous interferon synthesis are widely used. One of the well-known drugs in this group is CYCLOFERON

(NTFF "Polisan", St. Petersburg), which stimulates the production of a-, b- and g-interferon, which helps protect the body from infection by viruses, bacteria, protozoa, as well as inhibiting the growth of malignant cells. Antiviral properties are more characteristic of a- and b-interferon, the increase in the level of which determines the wide spectrum of antiviral action of CYCLOFERON. The use of the drug successfully prevents the development of relapses of viral infection. The immunoregulatory and antiproliferative properties of the drug are largely mediated through g-interferon. When the production of g-interferon is activated, CYCLOFERON normalizes the parameters of the T-cell immunity: the level of subpopulations CD3+ (T-lymphocytes), CD4+ (T-helpers), and CD16+ (natural killer cells), the number of which decreases in chronic and recurrent viral infections ; corrects the level of immunoglobulins M and E (IgM and IgE).

CYCLOFERON is available in various dosage forms: solution for injection 12.5% in ampoules of 2 ml No. 5 (registered in Ukraine in 1998), CYCLOFERON 5% LINIMENT in bottles of 5 ml (registered in Ukraine in 2001).

Urogenital chlamydia

, often accompanied by infertility, miscarriage, cervical diseases, chronic inflammatory diseases of the genital organs, as a rule, occurs against the background of suppressed T-cell immunity and impaired production of IgM and IgE, which complicates the treatment of patients. CYCLOFERON is used as an immunostimulant in addition to antibacterial therapy, taking into account the duration of the infectious process. Apply from 5 (for the treatment of patients with acute infections) to 10–20 injections of CYCLOFERON (for chronic infections) according to the scheme: 2 ml IM on the 1st, 2nd, 4th, 6th, 8th, 11th, 14th, 17th, 20th and 23rd days. When using CYCLOFERON, the effectiveness of therapy increases and the healing process accelerates.

In the scheme of complex treatment of patients with genital herpes

It is also advisable to include CYCLOFERON. In addition to the indirect effect on the virus through the immune system, CYCLOFERON has a direct effect, disrupting the process of viral replication, several times increasing the percentage of defective viral particles. The drug is used according to the scheme described above, and after 2-3 weeks the course of 5 injections is repeated. At the same time, CYCLOFERON 5% LINIMENT is used topically: the drug is administered intravaginally 1–2 times a day, 5 ml daily for 10–15 days. Recovery was noted in 88% of cases, clinical improvement - in 10% of cases; after recovery, stable remission occurred (Fedotov V.P. et al., 1999). To prevent relapses, CYCLOFERON therapy is combined with the administration of a herpetic vaccine. Before using the vaccine, 5 injections of CYCLOFERON are prescribed, after 1 day - a course of vaccination (5 injections of 0.1–0.2 ml every 72 hours). After 10 days the cycle is repeated.

It is believed that the increase in the number of patients and the low effectiveness of treatment of patients with urogenital candidiasis

are caused, in particular, by violations of the humoral and cellular immunity. The use of CYCLOFERON (according to the basic scheme - 8-10 injections) is justified if the duration of the process is more than 2 years, as well as in the presence of changes in the immunogram (Fedotov V.P. et al., 1999).

Prolonged course of gardnerella vaginitis

usually detected against the background of impaired immune status. The complex treatment of patients with a disease duration of more than 6 months includes 8–10 injections of CYCLOFERON to enhance the synthesis of endogenous interferon, which increases the effectiveness of specific therapy. For urogenital candidiasis and bacterial vaginosis, it is advisable to use CYCLOFERON 5% LINIMENT in the form of intravaginal instillations of 5–10 ml daily for 10–15 days, which significantly reduces the severity of symptoms of the disease (Isakov V.A., Aspel Yu.A., 1999) .

In the treatment of patients with external genital endometriosis

Along with hormonal, surgical, and enzyme therapy, the immunomodulator CYCLOFERON is used. To enhance the antiproliferative effect of the therapy, 2 courses of 5 injections of CYCLOFERON are prescribed at 2-week intervals, starting from the 1st day of the menstrual cycle (Ershov F.I. et al., 1999).

Good compatibility of CYCLOFERON with drugs traditionally used in the treatment of patients with the above diseases, as well as good tolerability, was noted. The drug is non-toxic, does not have an allergenic or carcinogenic effect, and local irritant effects are extremely rare. CYCLOFERON is contraindicated during pregnancy; systemic administration of the drug is contraindicated in severe liver dysfunction.

Detailed information, a list of references and texts of articles about CYCLOFERON can be found on the website of Medical Academy Pharmacies LLC www.ama.dp.ua

For questions regarding the purchase of the drug, please contact: 49044, Dnepropetrovsk, pl. Oktyabrskaya, 4, LLC “Pharmacies of the Medical Academy”; tel./fax

Contraindications

It is necessary to refuse treatment with the drug:

with uncompensated cirrhosis;
severe liver failure;
individual intolerance to components;
development of an allergy to the drug.

The medicine is also prohibited for the treatment of children under 4 years of age.

Those suffering from diseases of the gastrointestinal tract need to monitor their well-being when using tablets. In case of disturbances in the functioning of the endocrine system, treatment requires special care and medical supervision.