Dipentavak for dogs: instructions for use of the domestic drug

Content

1. Varieties 2. General information about the drug 3. How to use the drug correctly 4. Contraindications, possible negative consequences 5. Pros and cons 6. Existing analogues 7. Reviews

Pet owners should know: Dipentavak does not have any healing properties. The vaccine is administered solely for preventive purposes.

The formation of protective functions in the dog’s body occurs within 3 weeks. All this time the animal experiences increased stress. The effective period of protection against deadly infections lasts exactly 1 year. To maintain protective functions, annual revaccination is necessary. The dry component has a volume of 1.5 mm³, the volume of the suspension is 2.2 ml. The dry part of the preparation contains a live attenuated plague virus recorded in carnivores.

Corresponds to the Robcorn strain.

The second component is the rabies virus inactivated by ultraviolet rays (strain “Vnukovo-32”). The use of a stabilizer consisting of a mixture of gelatin and sucrose is provided as excipients.

The Dipentavak vaccination product consists of two main components that have a healing effect on the dog’s body:

Dipentavak, description

Varieties

When the drug is administered, a sufficient number of microorganisms enter the body, providing stable immunity to aggressive viruses. All these microorganisms are non-living, so they cannot harm the pet’s health, there is no threat. But the instructions for use specifically stipulate the procedure and correctness of the preparation of the vaccine and its administration.

The user should be aware that both components of the vaccine are contained separately, packaged in different glass containers. The sealing of the packaging is ensured by rubber stoppers secured with aluminum lids. Such precautions are necessary. When the medicine is taken into the syringe, not only is it sealed, but it is also protected from the penetration of bacteria.

• Pentavac.
  A substance in the form of a liquid in which congaria of parvovirus enteritis, hepatitis and other dangerous pathogens are dissolved.

The domestic pharmaceutical market is steadily developing, and the quality of developed medicinal products for animals is becoming better. Gradually, our drugs not only become worthy analogues of foreign vaccines and medicines, but also surpass them.

One of these remedies is deservedly Dipentavak, a drug consisting of several components (in carefully selected proportions). With its help, specialists form lasting protection against various types of infectious diseases. The most dangerous manifestations of etiology are rabies and plague; they almost always lead to death.

Instructions

INTERNATIONAL NON-PROPENTED NAME: ketoprofen

DOSAGE FORM: solution for injection

Ketoject in 1 ml as an active substance (AI) contains ketoprofen - 100 mg, as well as excipients: L-arginine 72 mg, benzyl alcohol - 10 mg, sodium hydroxide - 17.25 mg and water for injection up to 1 ml. In appearance, the drug is a colorless transparent solution. Ketoject is produced in dark glass bottles, sealed with rubber stoppers with aluminum caps. Each bottle is packaged individually in a cardboard box complete with instructions for use.

PHARMACOLOGICAL PROPERTIES

Ketoject belongs to the group of non-steroidal anti-inflammatory drugs. Ketoprofen, which is part of the drug, has a pronounced anti-inflammatory, analgesic and antipyretic effect. The mechanism of action is to suppress the synthesis of prostaglandins as a result of the effect on the metabolism of arachidonic acid. With intramuscular administration of Ketoject, the maximum concentration of ketoprofen in plasma is observed after 30-40 minutes. Ketoprofen is metabolized in the liver by glucuronidation. It is excreted primarily by the kidneys - 80% within 12 hours, mainly in the form of a glucuronic derivative. In renal failure, excretion slows down. In terms of the degree of impact on the body, Ketoject is classified as a moderately hazardous substance (hazard class 3 according to GOST 12.1.007-76), in recommended doses it is well tolerated by animals, and does not have embryotoxic, teratogenic or hepatotoxic properties.

ORDER OF APPLICATION

Ketoject is prescribed to cattle, horses and pigs as a symptomatic agent in the complex treatment of inflammatory reactions in acute and chronic diseases of the musculoskeletal system (arthritis, tendovaginitis, injuries, infectious lesions of the hooves) and the respiratory tract, MMA syndrome and other pathologies accompanied by acute inflammatory processes, as well as pain syndromes and hyperthermia of various etiologies. For cattle, Ketoject is administered intramuscularly or intravenously once a day at a dose of 3 mg of active substance per 1 kg of body weight or 3 ml of the drug per 100 kg of body weight for 1-3 days. For pigs, Ketoject is administered intramuscularly once a day at a dose of 3 mg of active substance per 1 kg of body weight or 3 ml of the drug per 100 kg of body weight for 1-3 days. For horses, Ketoject is administered intravenously or intramuscularly at a dose of 2.2 mg of ketoprofen per 1 kg of body weight or 1 ml of the drug per 45 kg of body weight. In the treatment of dysfunctions of the musculoskeletal and musculoskeletal systems daily, once a day for 3 to 5 days. For the symptomatic treatment of colic in horses, Ketoject is administered once at a dose of 1 ml per 45 kg of live weight. As a rule, one dose is sufficient; additional administration should be carried out after a preliminary re-clinical examination of the animal. If the next dose is missed, the use of the drug is resumed at the same dose, according to the same regimen. Slaughter of animals for meat after intramuscular administration of Ketoject is permitted no earlier than 4 days, and after intravenous administration - no earlier than 1 day after the last administration of the drug. The meat of animals forcedly killed before the expiration of the specified period can be used for animal feeding or for the production of meat and bone meal. During the period of use of Ketoject, milk can be used without restrictions.

CONTRAINDICATIONS FOR USE

Contraindications to the use of Ketoject are increased individual sensitivity of the animal to the components of the drug, stomach and duodenal ulcers, hemorrhagic syndrome, severe renal and liver failure.

OVERDOSE

In case of an overdose of the drug, the animal may experience decreased appetite, vomiting, and rarely bleeding from the gastrointestinal tract, hypotension/hypertension, and acute renal failure.

PECULIARITIES

No specific effects of the drug upon its first use and discontinuation were identified.

SIDE EVENTS

When using Ketoject in accordance with these instructions, side effects and complications in animals, as a rule, are not observed. In case of increased individual sensitivity to the drug and the appearance of allergic reactions, the animal is prescribed antihistamines and symptomatic therapy. Ketoject is not recommended for use simultaneously with other non-steroidal anti-inflammatory drugs, diuretics or anticoagulants. There is no information about the incompatibility of the drug with drugs from other groups and feed additives. Do not mix Ketoject with other drugs in the same syringe.

PERSONAL PREVENTION MEASURES

When working with Ketoject, you should follow the general rules of personal hygiene and safety precautions provided for when working with medications. Smoking, drinking and eating are not allowed during work. When finished, wash your hands with warm water and soap. In case of accidental contact of the drug with the skin or mucous membranes of the eyes, they must be rinsed with plenty of running water. People with hypersensitivity to the components of the drug should avoid direct contact with Ketoject. If allergic reactions occur or if the drug accidentally enters the human body, you should immediately contact a medical facility (bring with you the instructions for use of the drug or the label). It is prohibited to use empty drug containers for household purposes; they must be disposed of with household waste.

BEST BEFORE DATE

Store the drug in the manufacturer's sealed packaging, separate from food and feed, in a dry place, protected from direct sunlight, at a temperature of 5°C to 25°C. The shelf life of Ketoject, subject to storage conditions in the manufacturer's closed packaging, is 2 years from the date of production, after opening the bottle - 21 days. Do not use Ketoject after the expiration date.

General information about the drug

Your veterinarian will advise you on the need to use Dipentavac. Exclusively - based on the results of the examination, clinical tests, assessing the degree of risk of infection. All indications for use are described in detail in the instructions included with Dipentavak for dogs.

Dosage form

• Divac
  is a powdery substance containing plague strains, microorganisms that cause rabies.

Each glass container contains one dose for one-time administration of mixed powder and suspension. During packaging, the free space in the containers is filled with inert gas.

The vaccine can protect against major infections:

The standard release form is a set of two hermetically sealed glass ampoules. In one there is a dry powder, in the other there is a liquid substance, a suspension. It should be administered immediately after preparing the mixture as a single injection.

The composition of the drug includes the dry component (powder) “Divak”, which is a lifilizate necessary for the preparation of an injection solution. The second component of Pentavac is a liquid suspension. Both substances mixed immediately before injection constitute 1 dose.

In what cases is it recommended by a veterinarian:
The liquid component of the drug contains canine parvovirus (strains “D-1”, “LT”, “VGNKI-2” and “VGNKI-3”. All components are inactivated with formaldehyde, to which the adjuvant of aluminum hydroxide is added .

• Enteritis caused by parvovirus infection (especially aggressively affects the heart tissue and gastrointestinal tract of a four-legged pet);
• Canine distemper (caused by a zoonotic bacterium);
• The most dangerous pathologies of a respiratory nature (provoked by adenoviruses);
• Leptospirosis is a disease that causes damage to the liver, kidneys, capillaries, and muscle tissue, accompanied by general intoxication of the body.
• Rabies (scientific name - rabies), which severely affects the central nervous system (CNS);
• Hepatitis (causes devastating liver damage).

If left untreated, the disease can be fatal.

Vaccine Dipentavak for dogs (1 dose) 2 bottles vaccine + solvent

DESCRIPTION

Dipentavak is a vaccine against rabies, canine distemper, parvovirus enteritis, infectious hepatitis, adenovirosis and leptospirosis in dogs. In appearance, the dry component of the vaccine is a dry amorphous mass of light yellow color with a pink tint; the liquid component is a homogeneous suspension of pink color, which during storage forms a loose light gray sediment that easily breaks up when shaken.

COMPOUND

The dry component - "Divac" is made from live attenuated canine distemper virus, strain "Rockborn", and UV-inactivated rabies virus, strain "Vnukovo-32", lyophilized with the addition of a mixture of gelatin and sucrose as a stabilizer, 4% of the total volume.

The liquid component - "Pentavak" is made from canine parvovirus, strain "D-1", canine adenovirus of the second serotype, strain "LT" and leptospira serogroups Icterohaemorrhagiae (strain "VGNKI-2") and Canicola (strain "VGNKI-Z"), inactivated formaldehyde (at a concentration of 0.3%) with the addition of 3% aluminum hydroxide gel (at a concentration of 10%) as an adjuvant. There is no inhibitory effect of residual formaldehyde on live plague virus.

BIOLOGICAL PROPERTIES

The vaccine causes the formation of immunity in dogs to rabies, canine distemper, parvovirus enteritis, infectious hepatitis, adenovirosis and leptospirosis 21 days after double use of the vaccine in puppies and a single use in adult dogs, lasting 12 months.

One immunizing dose of the vaccine contains at least 1 IU/ml of rabies virus, at least 103.5 TCD50 of canine distemper, at least 103.0 GAE of canine parvovirus, at least 103.0 GAE of adenovirus, inactivated leptospira of the Icterohaemorrhagiae and Canicola serogroups at least 1.5 ×108.0 microbial cells of each serogroup.

The vaccine is harmless and has no medicinal properties.

DOSAGE AND APPLICATION

The Dipentavak vaccine is intended for immunization of dogs against rabies, canine distemper, parvovirus enteritis, infectious hepatitis, adenovirosis and leptospirosis.

Dogs are immunized from 60 days of age. The vaccine is administered subcutaneously or intramuscularly twice with an interval of 2-3 weeks.

Before use, shake the contents of the bottle with the liquid component and add 1.2 ml when vaccinating dogs weighing up to 5 kg or 2.2 ml when vaccinating dogs weighing more than 5 kg into the bottle with the lyophilized component, mix thoroughly until the dry component is completely dissolved. Sterile syringes and needles are used for vaccination. The injection site is not treated.

The next vaccination is carried out once after changing teeth in the same doses. Revaccination of dogs is carried out annually once at the same dose.

SPECIAL INSTRUCTIONS

Symptoms of rabies, canine distemper, parvovirus enteritis, infectious hepatitis, adenovirosis and leptospirosis or other pathological signs have not been established in case of an overdose of the vaccine.

The peculiarities of the post-vaccination reaction during the first and subsequent administrations of the vaccine have not been established.

Violation of the vaccination schedule should be avoided, as this may lead to a decrease in the effectiveness of immunoprophylaxis for rabies, distemper, parvovirus enteritis, infectious hepatitis, adenovirosis and leptospirosis. If the next dose of vaccine is missed, immunization should be carried out as soon as possible.

The use of specific serums and/or immunoglobulins is stopped 14 days before vaccination. After the specified period, unvaccinated animals are immunized.

CONTRAINDICATIONS

It is prohibited to vaccinate clinically sick and/or weakened animals, those with elevated body temperature, puppies under 60 days of age, puppies during the period of teeth change, pregnant bitches in the second half of pregnancy.

10 days before vaccination, dogs are dewormed.

SIDE EFFECTS

When using the vaccine in accordance with these instructions, there are usually no side effects or complications. If some animals develop allergic reactions to the vaccine, it is necessary to use antihistamines. The formation of slight swelling, some depression and temporary refusal of food are possible, which, as a rule, do not require medical intervention.

SHELF LIFE AND STORAGE

The shelf life of the vaccine is 18 months from the date of release, subject to storage and transportation conditions. After the expiration date, the vaccine is not suitable for use.

The vaccine is stored and transported in a dry, dark place at a temperature of 2 to 10°C and out of reach of children.

PACKAGE

The dry component of the Divac vaccine is packaged in 1 dose (1.5 ml) in sterile vials (ampoules, hermetically sealed) of appropriate capacity, filled with inert gas, hermetically sealed with rubber stoppers reinforced with aluminum caps.

The liquid component of the Pentavac vaccine is packaged in 1 dose (2.2 ml) in sterile vials (ampoules, hermetically sealed) of appropriate capacity, filled with inert gas, hermetically sealed with rubber stoppers reinforced with aluminum caps.

Vials of the vaccine are packaged in boxes of 5 doses (10 bottles). Each box of vaccine contains instructions for use.

Boxes with the vaccine are packed in boxes or other containers that ensure the integrity and safety of the vaccine.

How to use the drug correctly

1. Immediately before use, both components should be mixed.
2. First, you need to draw Pentavac into the syringe through a puncture in the cap.
3. It is then injected into the Divac vial.
4. The resulting mixture should be shaken thoroughly to ensure complete dissolution.
5. Refill the syringe with the resulting solution.
6. Before introducing the vaccine into the animal's muscles, the needle is changed to a new one.

The place of administration of the drug is subcutaneously, intramuscularly, in the scapular area. An injection into the muscle part of the thigh is allowed.

Contraindications, possible negative consequences

The practice of using Dipentavak did not reveal any deviations in the vital functions of pets.
It is not recommended to use vaccination for young puppies under 3 months of age; be careful with a pregnant female. The vaccine should not be administered to sick, malnourished animals or individuals with weakened immune systems. It is important to maintain proportions and then there will be no negative consequences:

• for body weight up to 5 kg, 1/2 ml of the product is allowed;
• if the animal weighs more than 5 kg, the dose is increased to 2.2 ml.

Side effects are minor. They are expressed by the appearance of small swellings at the site of needle insertion; for a certain period of time, the animal may lose its appetite.

Vaccine against rabies, canine distemper, parvovirus enteritis, infectious hepatitis, adenovirosis and leptospirosis in dogs

I. GENERAL INFORMATION. 1. Vaccine against rabies, canine distemper, parvovirus enteritis, infectious hepatitis, adenovirosis and leptospirosis in dogs - Dipentavac. 2. The Dipentavak vaccine consists of two components: dry - Divac and liquid - Pentavac. The dry component “Divac” is made from live attenuated canine distemper virus strain “Rockborn” and UV-inactivated rabies virus strain “Vnukovo-32”, lyophilized in a sucrose-gelatose medium. The liquid component of the Pentavac vaccine includes formaldehyde-inactivated canine parvovirus strain “D-I”, canine adenovirus of the second serotype strain “LT” and two Leptospira strains: “VGNKI-2” and “VGNKI-3” of the serological groups Icterohaemorrhagiae and Canicola. Aluminum hydroxide gel was added as an adjuvant. 3. In appearance, the dry component of the vaccine is a dry amorphous mass of yellowish-pink color, the liquid component is a homogeneous pink suspension, during storage of which a loose light gray sediment is formed, which easily breaks when shaken. II. BIOLOGICAL PROPERTIES 9. The Dipentavak vaccine induces immunity in vaccinated animals against pathogens of rabies, canine distemper, parvovirus enteritis, infectious hepatitis, adenovirosis and leptospirosis of dogs 21 days after double application of the vaccine in puppies and single application in adult dogs, which persists for 12 months. 10. The vaccine is harmless, areactogenic and has no therapeutic effect. III. ORDER OF APPLICATION 11. The Dipentavak vaccine is intended for the prevention of rabies, distemper, parvovirus enteritis, infectious hepatitis, adenovirosis and leptospirosis in dogs. 12. Only clinically healthy animals are subject to vaccination. Dogs are vaccinated starting from 60 days of age, twice with an interval of 2-3 weeks. Subsequent revaccination is carried out once after changing teeth. In the future, dogs are revaccinated once a year. The vaccine is administered subcutaneously into the scapula area or intramuscularly. 13. 10 days before vaccination, dogs are dewormed. The use of specific sera and immunoglobulins is stopped two weeks before vaccination. 14. Before immunization, the dry component of the Divac vaccine is dissolved in the liquid Pentavac. To do this, add 1.2 cm3 of the liquid component to the bottle (ampoule) with the dry component using a sterile syringe when vaccinating dogs weighing up to 5 kg and 2.2 cm3 of the liquid component when vaccinating dogs weighing more than 5 kg, shake thoroughly until completely dissolved and formed homogeneous suspension. Syringes and needles are sterilized by boiling for 20 minutes. Sterilization of syringes and needles with chemicals is not permitted. The use of disposable syringes is recommended. 15. In some cases, a small swelling may form at the injection site, disappearing within 3-5 days. Vaccinated animals are monitored for two weeks. 16. It is prohibited to vaccinate: - sick animals, - with elevated body temperature, - puppies under 60 days of age, - puppies during the period of teeth change, - pregnant females in the second half of pregnancy. IV. PERSONAL PREVENTION MEASURES 17. When working with the vaccine, you should follow the general rules of asepsis and antiseptics, personal hygiene and safety precautions provided for when working with veterinary drugs. 18. Protein and adjuvant components of the vaccine have an individual allergenic effect, therefore, all work with the vaccine must be carried out in an appropriate specialist. clothing with the mandatory use of personal protective equipment: robe, headdress, gauze mask, rubber gloves. 19. After work, you should wash your hands thoroughly with soap and change clothes. Places of work must have a first aid kit. Eating, drinking and smoking are prohibited in the workplace. 20. Accidental administration of the drug to the vaccinator may lead to a limited inflammatory reaction at the injection site. In this case, you must contact a medical facility. 21. The vaccine should be stored out of the reach of children.