Bubo-M is a separate combination vaccine designed to fight diseases such as hepatitis B, diphtheria and tetanus. The product is included in the vaccination calendar and is indicated for immunization of persons from 6 years of age with subsequent vaccination of adolescents and adults at risk.
Release form and composition
The vaccine is produced in the form of a suspension for intramuscular administration: homogeneous, white with a slight yellowish tint, which separates when standing into two fractions - a transparent colorless liquid and a loose white sediment with a light yellow tint, which is easily broken when shaken, and has no visible foreign inclusions ( 0.5 ml in ampoules, 10 ampoules in a blister pack, one blister pack in a cardboard box and medical instructions for use Bubo-M).
Composition per 0.5 ml (one vaccination dose):
- active ingredients: HBsAg (HBS protein, which is the main surface antigen of the hepatitis B virus) – 10 mcg; tetanus toxoid – 5 EU (antitoxin-binding units); diphtheria toxoid – 5 Lf (flocculating units);
- auxiliary components: aluminum hydroxide, merthiolate (thiomersal).
Reviews
Yuri : I am very careful about all kinds of vaccines, especially Russian ones - I’m afraid of complications. Therefore, before getting vaccinated with the recommended vaccine, I googled Bubo m vaccine instructions for use and received comprehensive information.
Having made up my mind, I did not regret my choice. There wasn’t even the slightest bit of discomfort, and I slept peacefully at night. I hope my review is useful to someone.
Svetlana, 33 years old : A doctor from a paid clinic recommended Bubo-M, especially since her daughter’s vaccinations were due. I wrote on the medical website: bubo m vaccine reviews and was satisfied with the properties of the drug.
However, literally a few hours after the injection, my child began to breathe heavily, and after some time her temperature rose to 40 degrees. Moreover, it was not easy to bring down the temperature.
Nurofen did not help at all and I had to use rectal suppositories. I managed to fall asleep only in the morning. The general malaise lasted about a week.
Pharmacological properties
When Bubo-M is administered in accordance with the approved vaccination calendar, specific immunity against diphtheria, tetanus and hepatitis B is formed.
Pharmacodynamics
The Bubo-M vaccine is a combination of diphtheria and tetanus toxoids, purified from ballast proteins, and recombinant yeast surface antigen of the hepatitis B virus (HBsAg), sorbed on aluminum hydroxide.
Pharmacokinetics
Data on the pharmacokinetics of Bubo-M are not provided.
Indications for use
Bubo-M is used in children over 6 years of age, adolescents, and adults to prevent tetanus, diphtheria and hepatitis B. The vaccine is administered in the following cases:
- conducting a vaccination course in children over 6 years of age who have not previously been vaccinated against tetanus, diphtheria and hepatitis B;
- planned age-related revaccinations (according to the ADS-M vaccine administration schedule) for children aged 6 years and older, adolescents and adults who have not previously been vaccinated against hepatitis B;
- coincidence of the timing of revaccination against tetanus and diphtheria with one of the vaccinations against hepatitis B (in children and adolescents).
Contraindications
Absolute contraindications for Bubo-M vaccination are:
- strong and unusual reactions to a previous injection of hepatitis B vaccine or diphtheria-tetanus toxoid (severe swelling, hyperemia at the injection site more than 8 cm in diameter, increased body temperature up to 40 ° C, etc.);
- exacerbation of chronic diseases and any diseases in the acute phase (until the end of the exacerbation);
- allergy to yeast and/or other vaccine components.
For acute intestinal diseases and mild acute respiratory viral infections, vaccination can be carried out immediately after body temperature normalizes.
Patients with chronic diseases are vaccinated after partial or complete remission. In case of neurological changes, progression of the process should be excluded and only after that should the Bubo-M vaccine be given. In patients with allergies, vaccination is carried out 2-4 weeks after the end of the exacerbation. Stable symptoms of allergic diseases (latent bronchospasm, localized skin manifestations) are not a contraindication to the use of the vaccine. In this case, the drug is administered against the background of appropriate treatment.
HIV infections, immunodeficiency conditions, maintenance course therapy (including psychopharmaceuticals and steroid hormones) are not contraindications to vaccination.
Bubo-M
A combination vaccine of hepatitis B and diphtheria-tetanus toxoid with a reduced content of antigens.
Manufacturer: CJSC NPK "Combiotech" (Russia).
Composition: a combination of recombinant yeast surface antigen of the hepatitis B virus (HBsAg) and diphtheria and tetanus toxoids purified from ballast proteins (ADS-M) adsorbed on aluminum hydroxide gel. Preservative - merthiolate.
Purpose: prevention of hepatitis B, diphtheria and tetanus in children over 6 years of age, adolescents and adults.
The vaccine is used: when conducting a course of vaccination for children over 6 years of age who have not previously been vaccinated against diphtheria, tetanus and hepatitis B; for planned age-related revaccinations (according to the ADS-M regimen) for children over 6 years of age, adolescents and adults who have not previously been vaccinated against hepatitis B; when the timing of revaccination of children and adolescents against diphtheria and tetanus coincides with one of the vaccinations of the hepatitis B vaccine course.
Directions for use: intramuscularly. Before vaccination, the ampoule must be thoroughly shaken until a homogeneous suspension is obtained. Subcutaneous administration of the drug and injection into the gluteal muscle are not recommended due to a decrease in the effectiveness of the hepatitis component and the possibility of increased local reactions.
Contraindications: strong (temperature above 40°C, swelling, hyperemia >8 cm in diameter at the injection site) and unusual reactions to previous administration of ADS toxoid or hepatitis B vaccine, as well as allergic reactions to yeast and other components of the vaccine. Routine vaccination is postponed until the end of acute manifestations of the disease and exacerbation of chronic diseases. Patients with chronic diseases are vaccinated upon achieving complete or partial remission. Persons with neurological changes are vaccinated after progression of the process has been ruled out. For patients with allergic diseases, vaccinations are carried out 2-4 weeks after the end of the exacerbation, while stable manifestations of the disease (localized skin phenomena, hidden bronchospasm, etc.) are not contraindications to vaccination, which can be carried out against the background of appropriate therapy.
For what diseases is the Bubo-M vaccine used?
- Hepatitis B - 24 hours, 1 month, 2 months, 6 months, 12 months, Adults
- Diphtheria - 3 months, 4.5 months, 6 months, 18 months, 7 years, 14 years, 24 years
- Tetanus - 3 months, 4.5 months, 6 months, 18 months, 7 years, 14 years, 24 years
What alternatives are there to the Bubo-M vaccine:
- ADS toxoid
- ADS-M toxoid
- DTP vaccine
- DT Vax
- Imovax D.T. Adultery
- Infanrix
- Pentaxim
- Tetrakok 05
We recommend reading:
Hepatitis B vaccine Bubo - M is a combined (ADS-M + HepB) vaccine for the combined prevention of diphtheria, tetanus and hepatitis B in adolescents.
Interesting thing about appearance :))) new shoes smell. best bandage for pregnant women. bubo m vaccine.
Answer to Anya Levchenko ...Russian manufacturers are already ready for such a development of events and have prepared the vaccine “Bubo - M” (ADS-M + hepB).
Vaccinations for special children ... waiting for the allergy to be removed. neurological other general local BCG, BCG-m8 23 ADS-m 8 8 2 6 ADS 1 1 1 DPT 90 70 20 4 3 3 60 AC 2 2 1 1 Bubo-coc 3 1 2 1 Polio vaccine 3 2 1 2.
Speech therapy intensive with Lynskaya M.I. Our review
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To the main page of the preventive vaccination calendar
Bubo-M, instructions for use: method and dosage
The Bubo-M vaccine is administered intramuscularly in a single dose of 0.5 ml into the deltoid muscle of the shoulder. Before use, shake the ampoule thoroughly until a homogeneous suspension is obtained.
It is not recommended to administer the vaccine subcutaneously or into the gluteal muscle, as this may reduce the effectiveness of the hepatitis component and intensify local reactions.
Primary vaccination schedule for children aged 6 years and older and adolescents who have not previously been vaccinated against tetanus, diphtheria and hepatitis B:
- first dose – on the selected day;
- second dose – 1 month after the first dose;
- third dose – 6 months after the first dose.
If it is necessary to increase the intervals between doses, Bubo-M vaccination is carried out as soon as possible, which is determined by the health status of the vaccinated person. If the interval between the first and second dose increases by 5 months or more, the third dose can be administered no earlier than 1 month after the second. Further revaccinations with ADS-M toxoid are established in accordance with the national vaccination calendar.
Persons previously vaccinated against tetanus and diphtheria, but who have not received the hepatitis B vaccine, are revaccinated with the Bubo-M vaccine once. Subsequently, missing hepatitis B vaccinations are given separately with hepatitis B vaccine in an age-appropriate dosage.
The drug in ampoules with damaged integrity, altered physical properties (the appearance of unbreakable flakes, change in color of the suspension), lack of labeling, if stored incorrectly and with an expired expiration date is not suitable for use.
To administer Bubo-M, you must use only a disposable syringe.
During opening of ampoules and vaccination, the rules of antisepsis and asepsis should be strictly observed. Opened ampoules with suspension cannot be stored. The administration of the vaccine is recorded in special accounting journals, which indicate the batch number, control number, manufacturer, expiration date and date of administration of the drug.
Using a similar serum
The medicine is intended for intramuscular administration. It belongs to the group of MIBP vaccines. Bubo-Kok is intended for the prevention of whooping cough, diphtheria and tetanus. The drug is prescribed to children under 4 years of age. The vaccine has contraindications.
- It is not prescribed for the development of pathology of the nervous system.
- A contraindication for use is complications that have arisen after the administration of other similar vaccines.
- Bubo-Kok is prohibited during exacerbation of chronic ailments. In this case, doctors recommend postponing vaccination.
A single dosage is 0.5 ml. When using the suspension, you must follow the preventive vaccination calendar. If necessary, the doctor increases the intervals between administrations. When using a vaccine, you need to monitor the body's reaction. Bubo-Kok can cause allergies. If such a symptom appears, urgent medical attention is required. Some patients may experience swelling and hyperemia. The injection area swells by 8 cm. If severe post-vaccination symptoms are detected, the doctor cancels further vaccinations.
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Side effects
The likelihood of side effects when administering Bubo-M is low. In 3–5% of cases, in the first two days after vaccination, short-term local (redness, swelling, soreness) and general (malaise, dizziness, fever, muscle and joint pain) reactions are possible.
In isolated cases, allergic reactions slightly worsened and side effects such as polymorphic rash, urticaria and Quincke's edema developed. In persons with hypersensitivity, immediate allergic reactions may occur, therefore, in the first 30 minutes after administration of the vaccine, it is necessary to monitor the vaccinated.
Anti-shock therapy should be available at vaccination sites.
Prevention of tetanus, diphtheria and hepatitis B
To protect the body from viral diseases, you need to know basic preventive measures, these include:
- timely vaccinations when a child reaches a certain age;
- proper nutrition;
- healthy sleep;
- timely and most importantly, professional treatment of diseases;
- refusal of self-therapy;
- use of sterile instruments in all conditions;
- rejection of bad habits;
- regular hand washing;
- avoiding contact with infected people;
- childbirth in a clinic;
- measures aimed at maintaining immunity.
Vaccinations against particularly dangerous diseases are not mandatory, however, they are recommended in municipal medical institutions. Before getting a vaccine, you need to analyze what side effects it can cause. If necessary, the drug is replaced with other serums that provide the same long-term prevention. The decision to vaccinate is made by the patient, taking into account the risk of getting sick and the characteristics of his body. Children need preventive vaccinations because their immunity is weaker. After administering the vaccine, you must follow all doctor's recommendations.
special instructions
The Bubo-M vaccine is included in the National Preventive Vaccination Calendar and is recommended for immunization of children over 6 years of age, as well as for revaccination of adolescents and adults who are at epidemiological risk groups for hepatitis B.
On the day of vaccination, a doctor or paramedic must conduct a survey of parents and/or an examination of the vaccinated person with mandatory temperature measurement to exclude possible contraindications. If adults are being vaccinated, it is possible to pre-select persons who need vaccination, followed by a survey and thermometry by the health worker performing immunization directly on the day of vaccination.
Patients who are temporarily exempt from vaccination are registered and monitored and must also be vaccinated in the future.
Special Recommendations
In some cases, Bubo-Kok is replaced with Bubo-M. If necessary, a second medication is administered after 90 days. Indications for stopping the vaccination are swelling of the soft tissues, the formation of an infiltrate of 2 cm in size. If febrile convulsions occur while using the drug, the doctor continues the administration, but prescribes a dose of paracetamol.
Vaccination may be recommended for patients who have suffered acute illnesses. In this case, it is carried out a month after treatment. If the pathology was mild, the doctor recommends administering it 2 weeks after recovery. Some patients experience mild bronchospasm. A possible side effect is skin rashes. In this case, the administration is not stopped. To achieve regression of these symptoms, the doctor carries out treatment.
Before using Bubo-Kok, you need to identify contraindications and assess the likelihood of adverse symptoms. The child is under medical supervision. The pediatrician opens the capsules in accordance with the rules for administering the vaccine. The serum must be new and tightly closed. If the packaging is damaged, the drug becomes unusable. If necessary, the doctor recommends analogues of Bubo-Kok.
