How to give Allokin-alpha injections - instructions (video)

The instructions for use of the drug Allokin-alpha claim that it is an effective treatment for human papillomavirus infection. The fact is that the drug is an excellent immunomodulatory and antiviral agent.

The medicine is produced in Russia (Moscow and St. Petersburg).

Side effects

The drug Allokin-alpha does not affect a person while driving a car.

As a result of taking it, the patient may experience such manifestations as:

• Muscle weakness;
• The appearance of rashes, itching at the injection site;
• Dizziness or pain in the head.

These conditions occur when the treatment is incorrectly formulated. Conditions such as:

• Wrong combination of drugs;
• Exceeding the dosage of medication;
• Failure to comply with contraindications;
• Violation of breaks between administrations;
• Poor body hygiene.

There has been no data on the development of an overdose, but doctors do not exclude the risk of its occurrence. If the drug is administered in large dosages, you should immediately call an ambulance for further advice.

ALLOKIN-ALFA lyophilisate for the preparation of solution for subcutaneous administration 1 mg No. 6

Allokin-alpha is an antiviral drug, a selective stimulator of the activity of natural immunity factors. Allokin-alpha is created on the basis of an artificially synthesized oligopeptide alloferon, which is similar in pharmacological action to alpha-interferon and is the main link in the antiviral defense of insects. Belongs to the group of antiviral drugs that “inhibit the shutdown of cytokines.” Allokin-alpha acts as a cofactor for the activation of the immune response, the formation of which requires the participation of the main signal - the viral antigen, which makes it possible to localize the effect of the drug at the site of inflammation, avoiding excessive reactions of the immune system beyond its boundaries. Allokin-alpha acts at the site of viral infection without activating the entire cascade of immunological reactions of the body. Allokin-alpha is an effective inducer of the synthesis of endogenous interferons and an activator of the natural killer system (NK or NK cells). Capable of stimulating the recognition and lysis of defective cells by cytotoxic lymphocytes. Helps restore the functional activity of T-cell immunity. Among the early reactions of the immune system to Allokin-alpha, an important place is occupied by the induction of interferon synthesis, which is most pronounced against the background of a viral infection. Allokin-alpha acts as a cofactor, allowing alpha-interferon-producing leukocytes to effectively respond to the main signal - the viral antigen. However, the induction of interferon synthesis occurs under the influence of the virus, and is not caused by the action of Allokin-alpha. This important feature underlies the specificity of the drug’s action - the production of this important cytokine occurs only in places of active viral replication. This reduces the risk of undesirable consequences of a generalized nonspecific response that occurs when using immunomodulatory drugs. Allokin-alpha enhances the production of interferon-gamma by NK cells in response to stimulation by interleukin-12. Allokin-alpha improves the recognition of virus-infected cells by NK cells, increases the cytotoxicity and functional activity of NK cells. Under the influence of Allokin-alpha, there is an increase in the expression of killing-activating receptors of NK cells, an improvement in the recognition of cells affected by the virus and their lysis, and an increase in the production of cytokines (interferon-alpha, interferon-gamma, interleukin-1, interleukin-2, lymphotoxin). Allokin-alpha promotes the expression of cytokine genes and, accordingly, increases the production of interleukin-6, interleukin-10, as well as interleukin-12 and interleukin-18. NK cells recognize virus-infected cells using killing-activating receptors, the expression of which increases under the influence of Allokin-alpha. An increase in interferon concentration is observed 2 hours after the administration of Allokin-alpha and remains at a high level (2-2.5 times higher than the usual background) for 6-8 hours with a decrease to initial values ​​by the end of the day. Increased functional activity of natural killer cells is observed within 7 days after the administration of Allokin-alpha. Experiments have demonstrated high effectiveness against infections caused by influenza A and B viruses, hepatitis C, and herpes. When treating genital herpes, Allokin-alpha eliminates pain and burning within several hours after the first injection, increases the period of remission by an average of 2 times, reduces the period of relapse by 2 times (from 6 days before treatment to 3 days during and after treatment) . Allokin-alpha is used in the treatment of papillomavirus infection with such manifestations as cervical erosion, condylomas, papillomas, flat and plantar warts. In more than 90% of cases of treatment of cervical erosion, the removal of the human papilloma virus from the body is observed. Effective for preventing the development of dysplasia and cervical cancer. After treatment with Allokin-alpha, manifestations of human papillomavirus infection disappear without additional surgical procedures if the above manifestations arose no earlier than 6 months before the start of treatment. Earlier neoplasms require an integrated approach to treatment using Allokin-alpha and destructive treatment methods. Allokin-alpha does not have general toxicity, does not have a hepato-nephrotoxic effect and toxic effect on the hematopoietic organs, a negative effect on indicators of immune and interferon status, does not have allergenic properties, mutagenic and carcinogenic effects, does not have an embryotoxic effect, does not affect reproductive function , does not cause addiction, does not have a cumulative effect, does not form resistant (resistant) forms of viruses. Does not have severe side effects. Based on preclinical and clinical studies, Allokin-alpha is recognized as meeting the highest requirements for drug safety. This does not exclude the possibility of individual intolerance to Allokin-alpha in some patients and the need for medical supervision over the course of treatment.

Mode of application

The drug must be administered every two days.
The total dosage to be administered for conditions that are in the progression stage is 6 injections. For herpetic infection, which is at the stage of progression, the drug Allokin-alpha is prescribed at a dosage of 1 mg.

The total dosage of Allokin-Alpha is 3 injections. For patients with moderate acute hepatitis B, the drug Allokin is prescribed 3 times a week.

Based on the patient’s condition and the severity of the disease, after a while the doctor can decide on the advisability of re-introducing the medicine.

Method of use of Allokin-Alfa

To prepare a solution for injection, the contents of the ampoule are dissolved in one milliliter of isotonic NaCl (sodium chloride) solution. It is not recommended to use other drugs as a solvent. It is prohibited to mix alloferon and other drugs for parenteral administration in the same syringe. The prepared solution should be used immediately after preparation. The regimen for using Allokin-Alfa and the duration of treatment are determined by the doctor.

As a rule, for infections caused by oncogenic types of human papillomavirus, 1 mg of alloferon is prescribed every two days. The recommended course dose of Allokin-Alfa is 6 injections.

During a relapse of herpes infection, 1 mg of alloferon is also prescribed every 48 hours. The total course dose is 3 injections.

For acute hepatitis B of moderate severity, the doctor, after making a diagnosis, recommends administering 1 mg of the drug three times a week. In this case, the course dose of Allokin-Alfa is 9 subcutaneous injections.

After some time, the attending physician may prescribe a second course. This depends on the patient's condition and the overall effectiveness of previous therapy.

How to inject Allokin-alpha correctly

The drug must be administered subcutaneously. The drug itself is painful, so you will have to be patient.

To administer the drug Allokin-alpha, it is necessary to gather the skin into a fold and insert a needle into its base at an angle of 45 degrees.

Photo instructions:

The medicine Allokin-alpha is used to prepare a solution. To do this, the contents of the ampoules must be dissolved in 1 ml of isotonic sodium chloride solution. Other medications should not be used as a solvent. It is not recommended to mix other parenteral medications in one syringe. It is recommended to use the solution immediately after its preparation.

Video

Allocoin-alpha during pregnancy

During pregnancy, you should stop taking this medication.
The substances included in the drug may have a negative effect on the fetus.

The use of the drug is also not allowed during breastfeeding. If the recommended requirements are not met, the child begins to develop serious diseases that become chronic. If it is not possible to replace the drug with a safe analogue, then the medication may be allowed, but only a doctor can decide this.

During menstruation, the use of the drug Allokin-alpha is allowed. If destruction is indicated (on the 6-7th day of treatment), then therapy begins on the first day of the cycle. If no destruction process is observed, then treatment can begin on any day.

Pharmacological action of Allokin-Alfa

Alloferon contained in Allokin-Alpha induces the synthesis of endogenous interferons and activates the natural killer system. It promotes the recognition and subsequent lysis of foreign cells by cytotoxic T lymphocytes.

Alloferon is low-toxic, very rarely causes allergic reactions, does not have mutagenic, embryotoxic or teratogenic effects, and is not carcinogenic. Clinical studies and reviews of Allokin-Alpha indicate that the drug does not affect the reproductive system of humans and animals.

Alloferon very quickly penetrates the bloodstream, where it interacts with cells. The products of its metabolism are similar in structure to blood plasma proteins, so their identification is difficult.

2 hours after using alloferon, the concentration of interferons in patients noticeably increases (2-2.5 times) and remains at this level for 6-8 hours. After a single administration of Allokin-Alpha, increased activity of natural killer cells persists for 6-7 days.

Price

When determining the cost of a drug, a number of factors are taken into account, which include transportation costs borne by the company, pharmacy markup, purchase price, and place of sale.

Important! For more information on prices, please contact your nearest pharmacy.

For 3 ampoules of the drug Allokin-alpha, on average you will have to pay 3,750 rubles. For 6 ampoules you need to pay 7890 rubles.

In Ukraine, 3 ampoules of Allcokin-alpha injections cost an average of 1,667 UAH, the price for 6 ampoules is 3,298 UAH.

Allokin-alpha, 1 mg, lyophilisate for solution for injection, 6 pcs.

Allokin-alpha is an antiviral drug, a selective stimulator of the activity of natural immunity factors. Allokin-alpha is created on the basis of an artificially synthesized oligopeptide alloferon, which is similar in pharmacological action to alpha-interferon and is the main link in the antiviral defense of insects. Belongs to the group of antiviral drugs that “inhibit the shutdown of cytokines.” Allokin-alpha acts as a cofactor for the activation of the immune response, the formation of which requires the participation of the main signal - the viral antigen, which makes it possible to localize the effect of the drug at the site of inflammation, avoiding excessive reactions of the immune system beyond its boundaries. Allokin-alpha acts at the site of viral infection without activating the entire cascade of immunological reactions of the body. Allokin-alpha is an effective inducer of the synthesis of endogenous interferons and an activator of the natural killer system (NK or NK cells). Capable of stimulating the recognition and lysis of defective cells by cytotoxic lymphocytes. Helps restore the functional activity of T-cell immunity. Among the early reactions of the immune system to Allokin-alpha, an important place is occupied by the induction of interferon synthesis, which is most pronounced against the background of a viral infection. Allokin-alpha acts as a cofactor, allowing alpha-interferon-producing leukocytes to effectively respond to the main signal - the viral antigen. However, the induction of interferon synthesis occurs under the influence of the virus, and is not caused by the action of Allokin-alpha. This important feature underlies the specificity of the drug’s action - the production of this important cytokine occurs only in places of active viral replication. This reduces the risk of undesirable consequences of a generalized nonspecific response that occurs when using immunomodulatory drugs. Allokin-alpha enhances the production of interferon-gamma by NK cells in response to stimulation by interleukin-12. Allokin-alpha improves the recognition of virus-infected cells by NK cells, increases the cytotoxicity and functional activity of NK cells. Under the influence of Allokin-alpha, there is an increase in the expression of killing-activating receptors of NK cells, an improvement in the recognition of cells affected by the virus and their lysis, and an increase in the production of cytokines (interferon-alpha, interferon-gamma, interleukin-1, interleukin-2, lymphotoxin). Allokin-alpha promotes the expression of cytokine genes and, accordingly, increases the production of interleukin-6, interleukin-10, as well as interleukin-12 and interleukin-18. NK cells recognize virus-infected cells using killing-activating receptors, the expression of which increases under the influence of Allokin-alpha. An increase in interferon concentration is observed 2 hours after the administration of Allokin-alpha and remains at a high level (2-2.5 times higher than the usual background) for 6-8 hours with a decrease to initial values ​​by the end of the day. Increased functional activity of natural killer cells is observed within 7 days after the administration of Allokin-alpha. Experiments have demonstrated high effectiveness against infections caused by influenza A and B viruses, hepatitis C, and herpes. When treating genital herpes, Allokin-alpha eliminates pain and burning within several hours after the first injection, increases the period of remission by an average of 2 times, reduces the period of relapse by 2 times (from 6 days before treatment to 3 days during and after treatment) . Allokin-alpha is used in the treatment of papillomavirus infection with such manifestations as cervical erosion, condylomas, papillomas, flat and plantar warts. In more than 90% of cases of treatment of cervical erosion, the removal of the human papilloma virus from the body is observed. Effective for preventing the development of dysplasia and cervical cancer. After treatment with Allokin-alpha, manifestations of human papillomavirus infection disappear without additional surgical procedures if the above manifestations arose no earlier than 6 months before the start of treatment. Earlier neoplasms require an integrated approach to treatment using Allokin-alpha and destructive treatment methods. Allokin-alpha does not have general toxicity, does not have a hepato-nephrotoxic effect and toxic effect on the hematopoietic organs, a negative effect on indicators of immune and interferon status, does not have allergenic properties, mutagenic and carcinogenic effects, does not have an embryotoxic effect, does not affect reproductive function , does not cause addiction, does not have a cumulative effect, does not form resistant (resistant) forms of viruses. Does not have severe side effects. Based on preclinical and clinical studies, Allokin-alpha is recognized as meeting the highest requirements for drug safety. This does not exclude the possibility of individual intolerance to Allokin-alpha in some patients and the need for medical supervision over the course of treatment.

Analogs

Among the Russian analogues of the drug Allokin-alpha, we can distinguish such drugs as: