Suprastin

Release form

The medicine has 2 forms: tablets 25 mg and solution d/i 20 mg/ml.

Suprastin tablets are disc-shaped, grayish-white or white. The name “SUPRASTIN” is engraved on one side and a line on the other. The smell is weak or completely absent. The tablets are packaged in blisters of 10 pieces, 2 blisters in a package.

The aqueous solution is transparent and colorless, with a slight specific odor. Available in ampoules with a capacity of 1 ml, package No. 5.

Pharmacodynamics and pharmacokinetics

The active substance of Suprastin is a chlorinated analogue of tripelenamine and belongs to the group of 1st generation antihistamines sedatives .

histamine receptors . Studies (both preclinical and clinical) prove its effectiveness in hay fever and other allergic diseases .

Like other H1 blockers, the action of the drug is aimed mainly at preventing immediate hypersensitivity reactions, and in cases where the reaction has already begun to develop, at preventing further histamine .

Experiments on guinea pigs showed that even in a very low dosage, the drug protected animals from the effects of histamine at a dose 120 times higher than the lethal dose.

Chlorpyramin also affects the central nervous system, capillary permeability and smooth muscle.

Absorption from the digestive canal after taking the required dose is rapid. The effect is observed 15-30 minutes after taking the tablet, reaches its maximum within 1 hour and lasts for up to 6 hours.

Chlorpyramin metabolized in the liver. Metabolic products are excreted mainly by the kidneys. Moreover, the drug is eliminated from the body of a child faster than from the body of an adult.

In patients with renal dysfunction, the elimination of chloropyramine may be reduced. With liver dysfunction , the metabolism of the substance slows down, which requires changing the dose of the drug.

Indications for use

Chloropyramine hydrochloride, a chlorinated analogue of tripelenamine (pyribenzamine), is a first-generation antihistamine that belongs to the group of ethylenediamine antihistamines. A blocker of histamine H1 receptors, has an antihistamine and m-anticholinergic effect, has an antiemetic effect, moderate antispasmodic and peripheral anticholinergic activity. The therapeutic effect of chloropyramine (in tablets) develops within 15-30 minutes after oral administration, reaches a maximum within the first hour after administration and lasts at least 3-6 hours. Indications:

• hives;
• serum sickness;

• seasonal and year-round allergic rhinitis;
• allergic conjunctivitis;
• contact dermatitis;
• skin itching;
• acute and chronic eczema;

• atopic dermatitis;
• food and drug allergies;
• allergic reactions to insect bites;
• angioedema (Quincke's edema) - for solution.

It is excreted mainly by the kidneys in the form of metabolites. Pharmacokinetics in special clinical situations. In children, drug elimination occurs faster than in adults. In patients with impaired liver function, the metabolism of chloropyramine is reduced, so the dose of Suprastin may be reduced. In patients with impaired renal function, the excretion of the active substance is reduced, so the dose of Suprastin may be reduced.

The most common remedy for fighting colds is paracetamol; it is included in many medications and can be used from three months. Read more in the article: “paracetamol tablets: dosage for children.”

Indications for use: what are Suprastin tablets and solution used for?

Suprastin tablets - what are they for?

Suprastin tablets are used in allergology:

• for the treatment of urticaria and allergies (nutritional or caused by insect bites), hay fever , serum sickness , allergic rhinopathy , dermographism , itching, conjunctivitis ;
• as an adjuvant for angioedema and systemic hypersensitivity reactions of the anaphylactic type .

The drug can also be prescribed to reduce swelling of the mucous membrane of the middle ear and nose during infections of the ENT organs ( sinusitis , otitis media ).

The combination “Suprastin - No-shpa - Analgin ” is used to reduce persistent hyperthermia . Suprastin ( antihistamine ) relieves swelling of the mucous membrane, No-shpa ( antispasmodic ) relieves spasms and promotes vasodilation, Analgin ( analgesic-antipyretic ) helps reduce temperature.

What does Suprastin in solution form help with?

Indications for the use of Suprastin in the form of a d/i solution are the same as for the tablet form of the drug.

What are the tablets used for?

Suprastin is produced in ampoules and tablets. In the form of injections, this medicine is used mainly in hospital settings, when it is necessary to eliminate severe manifestations of allergies (loss of consciousness, anaphylactic shock). Therefore, Suprastin tablets are most often purchased for the home first aid kit. What do they help with? Indications for their use are:

• rhinitis and conjunctivitis of allergic origin;
• contact dermatitis;
• hives;
• pathological reaction to medications, foods, insect bites, UV radiation.

What else does Suprastin help with? This antihistamine will help eliminate the characteristic signs of allergies: itching, cough, rash, swelling, low blood pressure - in other words, relieves its most painful symptoms. If you find Suprastin at home, then it is advisable to use it for infectious lesions of the ENT organs, which are accompanied by otitis media and a severe runny nose. This medicine will quickly relieve swelling in the nose and restore nasal breathing. Suprastin is given to children after vaccination, and to adults after tooth extraction. Also, do not forget that Suprastin should be given along with an antipyretic at high temperatures.

Phenibut is actively used in neurological and psychiatric practice. This is a domestic medicine that normalizes a person’s psycho-emotional state. Read more in the article: “how to take phenibut for adults.”

Contraindications

Contraindications for Suprastin:

• acute asthma ;
• stomach ulcer;
• angle-closure glaucoma;
• treatment with MAO inhibitors;
• arrhythmia;
• acute myocardial infarction;
• prostate hyperplasia;
• urinary retention;
• hypersensitivity to ethylenediamine ;
• allergy to the drug.

Side effects

Side effects of Suprastin from the central nervous system: increased fatigue, sedation , ataxia , dizziness , convulsions, tremor , headache, encephalopathy , decreased visual clarity, euphoria, drowsiness, impaired psychomotor functions.

From the cardiovascular system, arrhythmia , tachycardia , and arterial hypotension . From the digestive system: discomfort and pain in the epigastrium , dry mouth, diarrhea, nausea, vomiting, increased symptoms of gastroesophageal reflux , increased or complete lack of appetite.

On the part of the blood system, in rare cases, pathological changes in the blood may be observed (for example, agranulocytosis , hemolytic anemia , leukopenia , thrombocytopenia etc.).

From the organs of vision: ocular hypertension , glaucoma .

From the urinary system and kidneys: urinary retention, dysuria .

From the subcutaneous tissue and skin: hypersensitivity reactions, as well as a painful reaction to sunlight.

From the musculoskeletal system: myopathy .

Reactions of the immune system to the use of the drug can be expressed in the form of skin itching, rash, skin hyperemia, urticaria , angioedema .

Other side effects: changes at the injection site of the d/i ​​solution.

Instructions for use of Suprastin

Suprastin tablets: instructions for use. How to take Suprastin for adults?

The tablets should be taken with food, without crushing or chewing, and with liquid.

For adults, Suprastin tablets are prescribed to be taken at a dose of 75-100 mg/day. Exceed the dose of 100 mg/day. contraindicated.

Treatment is considered complete when all clinical symptoms are eliminated. If the above adverse reactions develop, the medication should be stopped.

How to take Suprastin if you have allergies if the disease is severe?

In acute severe conditions or anaphylactic shock, treatment begins with intravenous administration of the drug (intravenous injection should be performed very slowly). Subsequently, they switch to injecting the solution into the muscle or taking tablets.

The duration of use for severe allergies

Instructions for use of Suprastin in ampoules

Suprastin injections can only be given by a nurse or doctor.

The dosage of Suprastin for an adult is usually 1-2 ml/day. The drug is injected into the muscle. In especially severe cases, treatment begins with intravenous injections.

In case of liver dysfunction due to a decrease in the metabolism of the active substance, the patient may require a dose adjustment towards its reduction. A dose reduction is also necessary for patients with renal dysfunction , which is associated with the participation of this organ in removing chloropyramine from the body.

How many days should adults take Suprastin?

The duration of treatment depends on the severity of allergy and the body's sensitivity to chloropyramine . As a rule, the medicine is taken in short courses (5-7 days) when the process worsens. In case of severe disease, the doctor may make other prescriptions.

It should be remembered that with prolonged use of the drug, the patient may develop addiction to it.

Instructions for use of Suprastin for children

For children, the drug is prescribed for allergic reactions to medications, insect bites, food, eczema , taxidermy , urticaria , dermatitis , neurodermatitis and a number of other allergic diseases.

The use of Suprastin is also advisable for chickenpox : the drug can reduce the intensity of itching and somewhat calm the child’s nervous system.

Before giving Suprastin to children, you should read the list of contraindications. The use of tablets is contraindicated in children under 3 years of age; the solution is not prescribed to newborn infants (including premature infants).

In addition, you should not give the medicine in any form during an acute attack of asthma , intolerance to chloropyramine or any of the auxiliary components.

The manufacturer does not produce special children's Suprastin with a lower dosage of the active substance. There are no other dosage forms (ointment, drops, syrup) except tablets and solution.

How should children take Suprastin tablets?

Dosage of Suprastin for children under 6 years of age: 1 tablet/day, divided into 2 doses. According to the instructions, for children 6-14 years old the dose is 1-1.5 tablets/day. (0.5 tablets at each dose).

Depending on the body's response to treatment, the dose can be increased if necessary. The highest dose for a child is 2 mg/kg/day.

For infants, Suprastin tablets are prescribed, if necessary, 1/4-1/5 tablet. 2 rubles/day..

The solution, like the tablets, is dosed depending on the patient’s age: children under one year of age are administered 0.25 ml at the initial stages of treatment, children aged 12 months to 6 years - 0.5 ml, children aged 6- 14 years - from 0.5 to 1 ml.

Suprastin is contraindicated for newborns (including newborns born prematurely).

Injections are given with an insulin syringe with a needle for intramuscular injection. The maximum permissible dose of the drug is 2 mg/kg/day.

How should adults drink?

Before starting therapy, you need to carefully study the instructions in order to understand exactly how to take Suprastin for allergies in adults to quickly normalize well-being and prevent its deterioration. This drug is prescribed for food and respiratory allergies, as well as a reaction after contact with an allergen. It can be taken both as a prophylactic and to eliminate allergy symptoms. The peculiarity of this medicine is its short-term effect, so the tablets must be used at least 3 times a day to obtain the desired result. The dosage and frequency of use are selected by the doctor individually.

When answering the question of how much Suprastin to take for allergies in adults for prevention, it must be said that 1 tablet per day is enough. This will prevent a strong reaction from occurring.

According to the instructions for use of the Suprastin tablet, adults are prescribed for allergies 4 times daily every 6 hours.

The maximum daily dosage is 400 mg. This is enough for the main allergy symptoms to no longer bother you. The tablets are white and small in size. They taste bitter, so they need to be washed down with plenty of water. Many people are interested in how to take Suprastin for allergies by adults - before or after meals. It must be said that eating does not affect the speed of action of the drug and its effectiveness. How many days to take Suprastin for allergies in adults is determined separately for each person. The course of therapy generally lasts 5-7 days. The medicine can be used as part of complex therapy, but strictly as prescribed by the doctor.

Overdose

Accidental or intentional overdose, especially in children, can cause death.

atropine poisoning . They are expressed in the form:

• anxiety;
• hallucinations;
• athetosis;
• ataxia;
• seizures;
• impaired coordination of movements.

In young children, excitement predominates.

In some cases sinus tachycardia , dry mouth, facial flushing, fixed dilated pupils, fever, and urinary retention occur.

In adults, facial flushing and fever are observed intermittently, with periods of agitation followed by convulsive seizures and postconvulsive depression. The patient develops coma , cardiac and respiratory failure . Death occurs within 2-18 hours.

Cardiorespiratory monitoring as well as symptomatic therapy are recommended. Suprastin does not have a specific antidote.

Interaction

Simultaneous use with MAO inhibitors helps to prolong and enhance the anticholinergic effects of Suprastin.

With caution, the medicine is prescribed with: tranquilizers , sedatives (including sedative analgesics ), muscarinergic parasympatholytics , atropine , tricyclic antidepressants . This is due to the fact that in combination with Suprastin these drugs exhibit synergistic action.

Alcohol potentiates the inhibitory effect of chloropyramine on the central nervous system, and therefore, during treatment with Suprastin, drinking alcohol should be avoided.

special instructions

The annotation states that the drug should be used with caution in elderly people, as well as in patients with heart pathologies and liver failure .

If taken in the evening, the drug may increase the symptoms of gastroesophageal reflux .

It should be remembered that chloropyramine can cause depression and drowsiness, interfering with certain types of activity. They are especially pronounced at the initial stages of treatment.

The doctor determines the degree of restriction on working with machinery and driving vehicles individually for each patient.

Application in veterinary medicine

Chlorpyramin can be used for drug therapy of allergic conditions in animals.

It is given orally 2-3 times a day. at a dose of 0.3-0.5 mg/kg. When administered intramuscularly, the dose for a horse is 5-6 ml, for a pig weighing 70-100 kg - 1-2 ml, for dogs the dosage depending on weight is from 0.1 to 0.5 ml. Injections are given 2 times a day.

Suprastinex drops: dosage for children

Suprastinex is used for children of different ages. Drops are considered a more preferable form of release than tablets, which can only be taken by patients over 6 years of age. There are specific uses for different ages.

If the medicine is used to prevent complications after vaccination, the patient should be given the maximum permissible dose in accordance with age once a day. Treatment lasts up to 3 days, depending on the tolerability of a particular vaccine.

Suprastin's analogs

Level 4 ATC code matches:
Chloropyramine

Pharmaceutical equivalents of the drug are Chlorpyramin , Chlorpyramin-Ferein , Chlorpyramin-Eskom .

The price of analogues in tablets is 85-90 rubles. 10 ampoules of the solution will cost approximately the same amount.

Drugs similar in mechanism of action: Alepriv , Histafen , Diazolin , Kestin , Ketotifen , Clarotadine , Lomilan , Loratadine , Peritol , Rapido , Suprastinex , Telfast , Erius .

Which is better - Suprastin or Tavegil?

Tavegil , the active ingredient of which is clemastine , is a highly effective drug, similar in its action to diphenhydramine ( Diphenhydramine , Allergin , Benadryl ). Characterized by high anticholinergic activity.

Both products are 1st generation drugs. The duration of the effect produced and the intensity of action are comparable.

Which is better - Cetrin or Suprastin?

Cetrin ( cetirizine hydrochloride ) is a 2nd generation drug that is a highly selective H1-type histamine receptor antagonist.

The drug has 2 release forms - tablets, which are used in patients over 6 years of age, and syrup, which is prescribed from 2 years of age.

Cetirizine hydrochloride is practically not biotransformed in the body; the rate of its elimination is related to the functional state of the kidneys. A special feature of the drug is its ability to penetrate the skin well, which makes Cetrin especially effective for skin manifestations of allergies .

The medicine does not have a proarrhythmic effect , which has been proven in preclinical and clinical studies.

This means that the use of Cetrin is much less likely to be accompanied by the development of adverse reactions than the use of 1st generation products. Moreover, the degree of expression of the latter is also less than that of Suprastin.

If we talk about antiallergic activity , then Suprastin is considered a somewhat stronger remedy.

Which is better: Zyrtec or Suprastin?

Zyrtec is a generic version of Cetrin , since both of these drugs contain the same substance - cetirizine . Thus, Zirtec has the same advantages over Suprastin as Cetrin .

Which is better - Suprastin or Diazolin?

The active substance of Diazolin is a blocker of histamine receptors of subtype 1, mebhydrolin , like chloropyramine , belongs to the 1st generation drugs. In comparison with its analogue, the product is characterized by less antiallergic activity. The sedative effect is slightly pronounced.

Suprastin or Zodak - which is better?

Zodak is a 2nd generation antiallergic drug with prolonged action. Its basis is cetirizine dihydrochloride , a substance characterized by the ability to selectively block peripheral histamine .

Does not have a pronounced anticholinergic and antiserotonin effect . sedation (including drowsiness) when used in therapeutic doses.

Which is better: Loratadine or Suprastin?

Loratadine is a 2nd generation antihistamine, which is characterized by high binding strength to peripheral histamine . It has no sedative effect , does not have cardiotoxic effects and does not enhance the effects of alcohol.

Loratadine practically does not interact with other medications.

Which is better: Suprastin or Claritin?

Since the active ingredient of the drug Claritin is loratadine , the choice between it and Suprastin should be made taking into account the features described above.

Alcohol and Suprastin

The drug is incompatible with alcohol.

What is Suprastin? This is antiallergic drug . Like other drugs from this group, it has a pronounced anticholinergic , hypnotic and sedative effect , which is enhanced in combination with alcohol.

Suprastin and alcohol: consequences of simultaneous use

Drinking alcohol during treatment with Suprastin can provoke symptoms such as:

• dizziness;
• blurred vision;
• a state close to panic;
• nervous excitability;
• dry mouth;
• euphoria;
• unstable stool;
• nausea;
• convulsions;
• vomit;
• tremor;
• tachycardia;
• ocular hypertension;
• a sharp drop in blood pressure;
• arrhythmia;
• urinary retention;
• lethargy;
• drowsiness.

Suprastin and alcohol: compatibility

Suprastin and alcohol taken together increase the load on the liver to indecent limits. As with the use of antibiotics and alcohol, nothing may happen if the person being treated has a healthy liver and other internal organs. Only in this case is combined use allowed. Of course, they will put a strain on the body, but nothing bad will happen. But is it worth the risk? Of course, it may be that at the height of spring allergies you need to go to an anniversary or a wedding, but you should not combine these remedies within yourself. It’s better then to choose just one thing. Those who have treated allergies with suprastin probably know that this drug can cause drowsiness or even slight dizziness. That is why it is undesirable to use suprastin when you are driving.

Suprastin and alcohol, the consequences of taking which can be completely different, can only double each other’s effect.

Let's say that intoxication will occur much faster and with less ethanol. Do not forget about the therapeutic effect that suprastin provides; interaction with alcohol can neutralize it.

Thus, in addition to intoxication, you can also get a reverse allergic effect, which can also be dangerous for the human body. Symptoms of nausea, loss of sleep, dizziness and apathy can also appear if you use suprastin and alcohol, the compatibility of which has been quite well studied.

Suprastin during pregnancy and breastfeeding

Can pregnant women take Suprastin?

There are no data from preclinical studies on the use of the drug during pregnancy.

Adequate studies with proper control of the use of the drug in pregnant women have also not been conducted. However, there is evidence that in newborn infants whose mothers took antihistamines , connective tissue developed behind the lens of the eye.

In the description of the drug, the manufacturer warns that the use of Suprastin - especially in the 1st trimester and in the last weeks of the 3rd trimester - is possible only after a careful assessment of the beneficial effects and possible risks.

As for use in the 2nd trimester, the drug is also prescribed during this period after the risks to the fetus and the benefits to the mother’s body have been analyzed.

Thus, the question of whether Suprastin can be taken during pregnancy can only be answered by a doctor monitoring a pregnant woman.

Suprastin during lactation: can nursing mothers take antihistamines?

In the absence of well-controlled, adequate data on the use of the drug in breastfeeding, it is not recommended for use in breastfeeding women.

Dosage of Suprastin for children

The frequency of taking the medication depends on the severity of allergic manifestations. For mild manifestations, the drug can be given to children once a day. Allergies with severe manifestations require three doses of medication. The instructions for using Suprastin for children warn that they should not take the medicine for more than a week. Long-term use is fraught with side effects. If the symptoms do not subside within a week, then you need to adjust the treatment with the help of a doctor.

In some emergency situations, such as insect bites, suprastin is prescribed for infants. Therefore, if you have an infant, you need to know in advance what doses of the drug are safe for a newborn. Children up to one year old are given one tablet per day, divided into four parts in 2-3 doses. How to give medicine to a baby if he can’t swallow a pill, and the baby won’t be able to give an injection. Therefore, a suspension is prepared: the required amount of medicine is ground into powder, diluted with water (breast milk) and carefully poured over the cheek from a spoon or given from a nipple.

Suprastin is given to children under 3 years old by analogy with infants. If the allergic manifestations are severe, then you will have to give an intramuscular or intravenous injection, so the medicine will work faster. For children from one month to three years, the daily dosage should not exceed 2 mg per kilogram of body weight. For example, the baby’s weight is 4 kg, which means the dosage is 8 mg per day. You can use this medicine yourself only to provide emergency care once, after which you should immediately contact a doctor.

Reviews about Suprastin

Reviews of Suprastin for children and adults prove the high antihistamine activity of this drug. The product is effective for the treatment of allergic rhinoconjunctivitis (both year-round and seasonal), urticaria , Quincke's edema , eczema , atopic dermatitis , itching of various etiologies.

In parenteral form, the drug has proven itself well in conditions that require emergency care.

The advantages of the drug are proven effectiveness, a wide range of therapeutic doses used, speed of action, short duration of side effects, controllability of the clinical effect, low cost. The active substance of the drug does not accumulate in the serum, which eliminates the possibility of overdose with long-term use.

Wikipedia indicates that Suprastin is included in the Russian list of vital and essential drugs.

How long does it take for Suprastin to work?

The antihistamine drug Suprastin for allergies has been successfully used for a long period of time to relieve any conditions that are associated with the uncontrolled process of histamine release. In emergency cases, injectable forms for intramuscular and intravenous administration are used to quickly eliminate negative symptoms. For long-term treatment of chronic diseases, it is recommended to use Suprastin tablets in dosages recommended by the attending physician, taking into account the age and condition of the patient.

Can be used in complex therapy of allergic diseases in both children and adults.

Suprastin is contraindicated during pregnancy. However, sometimes exceptions are made, this is due to its versatility, speed and low price. The 1st trimester in this regard is the most important due to the beginning of the formation of all vital organs.

The negative impact of the drug during this period is considered maximum. According to some studies, when a pregnant woman takes Suprastin, a miscarriage or developmental defects in the baby are possible. Therefore, the drug is not prescribed.

How much do Suprastin tablets and injections cost?

The price of Suprastin tablets in Russia is from 110 rubles. The price of Suprastin in ampoules is from 150 rubles.

The average price in Ukraine for tablets 25 mg No. 20 is 65 UAH, the price of Suprastin 25 mg No. 10 is from 29 UAH. The d/i ​​solution can be purchased in pharmacies in Kharkov and Kyiv for 67-85 UAH. At the same time, the cost of 1 ampoule is 14-16 UAH.

For patients who are more comfortable using drops, Egis has developed the drug Suprastinex based on levocetirizine. Its cost is from 1060 rubles. in Russian, and from 350 UAH in Ukrainian pharmacies.

• Online pharmacies in RussiaRussia
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ZdravCity

• Suprastin tab.
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• Suprastin solution for intravenous and intramuscular injection. 20mg/ml 1ml 5 pcs. Egis

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• Suprastin tab. 25 mg No. 40 ZAO Pharmaceutical Plant EGIS

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Pharmacy Dialogue

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Pharmacy24

• Suprastin 20 mg/1 ml No. 5 solution ZAT FZ Egis, Ugorshchina
  78 UAH. order
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